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  • Author or Editor: K Szabó x
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Abstract  

During recent years, knowledge of rheumatoid arthritis has increased, and management of the disease has improved. A limited number of papers have been published before on the subject of thermal analysis of degenerative cartilage but rheumatoid arthritis (RA) has not been studied previously. A new protocol had to be established before the investigation. The purpose of this study was to further characterize the altered metabolism in human RA cartilage that promotes disease progression. Previously, these methods have not been used for this purpose. The use of thermal analysis could be an effective method for controlling the relationship between biomarkers and disease progression.

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Abstract  

Shoulder pain is a common presentation of the dysfunction of the glenohumeral joint. The long head of the biceps tendon has been proposed as a source of pain in rotator cuff pathologies. The rotator cuff is a dynamic stabilizer of the glenohumeral joint, and its tear can create different shoulder dysfunctions. The long head of the biceps has a special intraarticular localisation, so the arthricular destruction affects its tendon too. In the process of the rotator cuff degeneration and tear the structure of the biceps tendon pathological transforms. With foregoing studies authors have demonstrated the feasibility of DSC in the investigation of the musculoskeletal system. The aim of this study was to establish the curves and the histological properties of the tendon of the long head of the biceps in different magnitudes of the rotator cuff tear on cadavers. The DSC results clearly proved that definitive differences are present between the structural state of the tendons in different magnitudes of the rotator cuff tears, which have also been demonstrated by the histological examination.

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Abstract  

Osteoarthritis, although classically conceived of as a degenerative consequence of aging, is a disease with an increasingly well-characterized molecular pathophysiology. Pathologic changes in cartilage composition and molecular organization, as well as elevated water content, alter the exquisite balance of biomechanical properties. Much of what is known about changes in the extracellular matrix in osteoarthritis comes from animal models. Previously, thermogravimetric methods have not been used for compositional thermoanalytical study of normal and degenerative human hyaline cartilage. For this reason the research group established a sufficient new thermogravimetric protocol, which proved water content elevation contributing to disease progression.

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Abstract  

A control system for monitoring the radioactive concentration in aqueous wastes of nuclear installations was elaborated. The mobile station developed for in situ control enables simultaneous measurement of gamma radiation in the energy range of 0.15–2.0 MeV and that of beta radiation in the energy range of 0.3–2.0 MeV by means of a combined scintillation detector. Disturbing effects of accompanying and secundary radiations on the determination of the counting efficiency vs. radiation energy functions used in calculation of the radioactive concentration limits as well as some experiences during a long time of operation of the system have been discussed.

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Effects of mixed cultures of Saccharomyces cerevisiae Levuline FB — higher ethanol tolerance — and different Kluyveromyces strains — higher inulinase activity — on the production of ethanol from Jerusalem artichoke extract were investigated. Among the investigated strains, combination of S. cerevisiae and K. marxianus strain Y00959 with simultaneous saccharification and fermentation gave the best efficiency (76%) of bioconversion. The optimal ratio of mixed cultures was determined to be 1:1 of K. marxianus and S. cerevisiae. Central composite design (CCD) was adapted to find the optimum initial substrate concentration and inoculum size for the maximal production of ethanol from Jerusalem artichoke juice. The optimum fermentation conditions were found to be 24% (m/w) substrate concentration and 45 OD600nm ml/100 ml inoculum size of mixed culture. Use of these conditions, about 10.67% (v/v) was produced at 148 h of alcoholic fermentation given. Results of this work provide benefits of mixed culture on production of bioethanol from Jerusalem artichoke.

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Abstract

Number of people over 65 years is continuously increasing and represents an ever growing proportion of population even in Hungary. Medical treatment of the elderly implies a massive burden for the healthcare system. Special knowledge is required to provide an appropriate medical care for the elderly. During the ageing process, several changes accumulate in the body and several chronic diseases develop. Function of parenchymal organs is impaired, healing process is slower, clinical manifestations of diseases are not so prominent, the diagnosis is often difficult to establish. Moreover, treatment possibilities also differ, because pharmacokinetics and pharmacodynamics of drugs are different from that of young patients. Communication with older patients is also cumbersome, participation of a relative or caregiver at consultation can be useful. Cardiovascular diseases remain the leading cause of death of adults over the age of 65. Among these diseases congestive heart failure, coronary artery diseases, hypertension, atrial fibrillation have the greatest significance.

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Abstract  

The purpose of this investigation was to further elucidate calorimetric properties of cartilage samples from femoral head necrosis and osteoarthritis from live surgeries. The natural course of this disease is one of steady progression with eventual collapse of the femoral head, followed by secondary osteoarthritis in the hip joint. All samples showed a clear denaturation peak on the calorimetric curve. Cartilage obtained from necrotic femoral head required the lowest amount of energy for decomposition. The use differential scanning calorimetry as part of thermal analysis was a reliable method for differentiating.

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Wild Origanum vulgare populations in Hungary have been analysed. In 2010 the morphological variability of 11 populations in five shires was investigated, the features of habitats were also described. The difference in elevation between the lowest and highest locality is 630 m. Nine plant associations, four soil types, variable pH between 4.81–7.96 and humus content from 0.54% to 6.97% were determined. Among the examined individual plants the maximum length of stem was 107 cm, the highest number of branches was 14 pairs, furthermore procumbent and mellow stems were also found. The defined colours of inflorescences are dyes of pink or purple. Despite to these we found individuals in one population with white flowers, green bracts and calyces.

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The suitability of benthic diatoms in the biological monitoring program of the water quality of Lake Velence was tested. Diatom indices were calculated with the aid of the software Omnidia based on reed periphyton samples collected between 1988 and 1990, and 1999 to 2004. We have pointed out which indices are appropriate for indicating the water quality changes of Lake Velence. The correlation between the indices IBD, IPS, IDG, and the total nitrogen, total phosphorus content of the water and chlorophyll-a content of the periphyton was calculated. Significant negative correlation was found between the indices and the total phosphorus content of the water. Moreover, we concluded that the chlorophyll-a content of the periphyton related to surface area can also provide information about the water quality. Based on these results the index IBD seems to be the most suitable for the water quality analysis of Lake Velence. Recommendations are provided here concerning the ecological status classification of Lake Velence based on epiphytic diatoms; unaccounted questions and future assignments are also outlined in connection with this.

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