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Acta Chromatographica
Authors:
A. Ochoa
,
J. Fechine
,
J.C. Escalona
,
J. García
,
S.G. dos Santos
, and
M. Sobral da Silva

Excoecaria lucida Sw. is an evergreen shrub widely distributed in Cuba and throughout the Caribbean region. In spite of its extended traditional use as antiasthmatic and antimicrobial by the local population, scientific reports on the species are almost nonexistent. This paper focuses on the isolation and characterization of compounds present in the crude extract of E. lucida Sw. leaves through the combined use of chromatographic and spectroscopic techniques (medium pressure liquid chromatography, thin-layer chromatography, gas chromatography, nuclear magnetic resonance 1H, and mass spectrometry). A total of 15 nonpolar substances were identified in the four main fractions obtained; some of these substances could be related with the antimicrobial properties attributed to the species.

Open access
European Journal of Microbiology and Immunology
Authors:
C. Alvarado-Esquivel
,
S. J. Pacheco-Vega
,
M. Salcedo-Jaquez
,
L. F. Sánchez-Anguiano
,
J. Hernández-Tinoco
,
E. Rábago-Sánchez
,
M. M. Centeno-Tinoco
,
I. D. Flores-Garcia
,
A. Ramos-Nevarez
,
S. M. Cerrillo-Soto
,
C. A. Guido-Arreola
,
I. Beristain-García
,
O. Liesenfeld
,
L. O. Berumen-Segovia
,
L. Saenz-Soto
, and
A. Sifuentes-Álvarez

Through a cross-sectional study design, 150 women attending public health centers with a history of stillbirths were examined for anti-Toxoplasma gondii IgG and IgM antibodies in Durango City, Mexico. Bivariate and multivariate analyses were used to assess the association of T. gondii seropositivity with the characteristics of the women with stillbirth history.

Of the 150 women (mean age: 32.09 ± 9.16 years) studied, 14 (9.3%) had anti-T. gondii IgG antibodies and six (42.9%) of them were also positive for anti-T. gondii IgM antibodies. Multivariate analysis showed that T. gondii seropositivity was associated with high frequency (4–7 days a week) of eating meat (OR = 5.52; 95% CI: 1.48–20.59; P = 0.01), history of lymphadenopathy (OR = 4.52; 95% CI: 1.14–17.82; P = 0.03), and history of surgery (OR = 8.68; 95% CI: 1.04–72.15; P = 0.04).

This is the first study on the seroepidemiology of T. gondii infection in women with a history of stillbirths in Mexico. The association of T. gondii exposure with a history of surgery warrants for further research. Risk factors for T. gondii infection found in the present survey may help to design optimal educational programs to avoid T. gondii infection.

Open access
Journal of Radioanalytical and Nuclear Chemistry
Authors:
J. D. T. Arruda-Neto
,
A. C. Cestari
,
C. B. Zamboni
,
M. Saiki
,
G. P. Nogueira
,
L. E. C. Fonseca
,
M. V. Manso-Guevara
,
A. Deppman
,
V. P. Likhachev
,
J. Mesa
,
O. A. M. Helene
,
S. A. C. Jorge
,
M. N. Martins
,
A. N. Gouveia
,
O. Rodriguez
,
F. Guzmán
, and
F. Garcia

Summary  

Neutron activation analysis has been used to study uranium incorporation in poultry bones as function of chow doped with: (a) uranium (20 ppm); (b) U-doped food (20 ppm) plus phytase (120 ppm) and (c) U-doped food (20 ppm) plus phytase (180 ppm). To investigate this situation experiments involving several groups of Cobb broilers was performed. Two animals per group were sacrificed weekly up to their adultness and uranium concentration in the tibia was measured. It was observed that the concentration of uranium (µg U/g bone) is decreasing all along the animal life spanning period of 14-42 days. This behavior suggests that the skeleton mass is growing faster than the corresponding accumulation of uranium. The administration of phytase seems not to alter this scenario.

Restricted access
Physiology International
Authors:
Driele N. Garcia
,
Jéssica D. Hense
,
Bianka M. Zanini
,
José V. V. Isola
,
Jorgea Pradiee
,
Juliane B. Prosczek
,
Joao A. Alvarado-Rincón
,
Rafael G. Mondadori
,
Jeffrey B. Mason
,
Miguel A. Brieño-Enríquez
,
Carlos C. Barros
,
Michael B. Stout
,
Michal M. Masternak
, and
Augusto Schneider

Abstract

Cellular senescence is a defense mechanism to arrest proliferation of damaged cells. The number of senescent cells increases with age in different tissues and contributes to the development of age-related diseases. Old mice treated with senolytics drugs, dasatinib and quercetin (D+Q), have reduced senescent cells burden. The aim of this study was to evaluate the effects of D+Q on testicular function and fertility of male mice. Mice (n = 9/group) received D (5 mg kg−1) and Q (50 mg kg−1) via gavage every moth for three consecutive days from 3 to 8 months of age. At 8 months mice were breed with young non-treated females and euthanized. The treatment of male mice with D+Q increased serum testosterone levels and sperm concentration and decreased abnormal sperm morphology. Sperm motility, seminiferous tubule morphometry, testicular gene expression and fertility were not affected by treatment. There was no effect of D+Q treatment in β-galactosidase activity and in lipofuscin staining in testes. D+Q treatment also did not affect body mass gain and testes mass. In conclusion, D+Q treatment increased serum testosterone levels and sperm concentration and decreased abnormal sperm morphology, however did not affect fertility. Further studies with older mice and different senolytics are necessary to elucidate the effects in the decline of sperm output (quality and quantity) associated with aging.

Restricted access