Search Results

You are looking at 51 - 56 of 56 items for

  • Author or Editor: P. Thomas x
  • Refine by Access: All Content x
Clear All Modify Search

Background

Internet gaming disorder (IGD) was introduced in the DSM-5 as a way of identifying and diagnosing problematic video game play. However, the use of the diagnosis is constrained, as it shares criteria with other addictive orders (e.g., pathological gambling).

Aims

Further work is required to better understand IGD. One potential avenue of investigation is IGD’s relationship to the primary reinforcing behavioral functions. This study explores the relationship between duration of video game play and the reinforcing behavioral functions that may motivate or maintain video gaming.

Methods

A total of 499 video game players began the online survey, with complete data from 453 participants (85% white and 28% female), were analyzed. Individuals were placed into five groups based on self-reported hours of video gaming per week, and completed the Video Game Functional Assessment – Revised (VGFA-R).

Results

The results demonstrated the escape and social attention function were significant in predicting duration of video game play, whereas sensory and tangible were not significant.

Conclusion

Future implications of the VGFA-R and behaviorally based research are discussed.

Open access
Journal of Radioanalytical and Nuclear Chemistry
Authors:
D. Robertson
,
A. Schilk
,
K. Abel
,
E. Lepel
,
C. Thomas
,
S. Pratt
,
E. Cooper
,
P. Hartwig
, and
R. Killey

Abstract  

In order to more accurately predict the rates and mechanisms of radionuclide migration from lowlevel waste disposal facilities via groundwater transport, ongoing studies are being conducted at field sites at Chalk River Laboratories to identify and characterize the chemical speciation of mobile, long-lived radionuclides migrating in groundwaters. Large-volume water sampling techniques are being utilized to separate and concentrate radionuclides into particulate, cationic, anionic, and nonionic chemical forms. Most radionuclides are migrating as soluble, anionic species which appear to be predominately organoradionuclide complexes. Laboratory studies utilizing anion exchange chromatography have separated several anionically complexed radionuclides, e.g.,60Co and106Ru, into a number of specific compounds or groups of compounds. Large-volume ultra-filtration experiments have shown that significant fractions of the radionuclides are being transported in these groundwaters in the form of macromolecules having molecular weights ranging from less than 3,000 to 100,000.

Restricted access
Acta Chromatographica
Authors:
A. B. Thomas
,
U. B. Chavan
,
R. K. Nanda
,
L. P. Kothapalli
,
S. N. Jagdale
,
S. B. Dighe
, and
A. D. Deshpande

Summary

Simultaneous analysis of atenolol (Atn), hydrochlorothiazide (Hctz) and losartan potassium (Los) in solid dosage forms has been achieved by reversed-phase high-performance liquid chromatography on a C18 column with a 0.035 M potassium dihydrogen orthophosphate-acetonitrile gradient as mobile phase and UV detection at 225 nm. The retention times for Atn, Hctz, and Los were 2.91, 4.75, and 7.52 min, respectively, with mean recoveries of 99.67, 99.89, and 100.69%. The method was validated in accordance with ICH guidelines. Because of its simplicity and high precision and accuracy, the method can be used for analysis of atenolol, hydrochlorothiazide and losartan potassium in pharmaceutical preparations.

Open access

Summary

Genetic mutations, chromosomal breaks, and chromosomal rearrangements, which are induced due to organic impurities, are considered as potential genotoxic impurities. The European Medicines Agency (EMA) and the United States Food and Drug Administration (US FDA) have set a threshold of toxicological concern (TTC) of 1.5 µg per person per day for each impurity. A sensitive and simple high-performance thin-layer chromatography (HPTLC) method has been developed and validated for determination of the potential genotoxic impurity, namely, 2-chloroaniline, at trace levels in quetiapine fumarate. The method was found to be specific and selective for the application. The limit of detection (LOD) and limit of quantification (LOQ) for quetiapine fumarate were found to be 1.27 and 3.87 ng per band. The LOD and LOQ values for 2-chloroaniline were found 0.018 and 0.054 ng per band, respectively. The calibration curve for 2-chloroaniline was linear over a concentration range from 2.5 to 12.5 ng. The method was found to be specific, precise, linear, and accurate and can be employed for monitoring and estimation of levels of 2-chloroaniline in quetiapine fumarate.

Restricted access
Journal of Psychedelic Studies
Authors:
Thaddeus James Camlin
,
Donald Eulert
,
Arthur Thomas Horvath
,
Steven F. Bucky
,
Joseph P. Barsuglia
, and
Martin Polanco

Background and aims

This study examined the lived experience of individuals who underwent ibogaine treatment for an opioid use disorder.

Methods

Semi-structured interview questions probed for potential changes in predetermined categories derived from a literature review. Participants’ experiences with ibogaine were analyzed for commonalities and emergent themes.

Results

Categories that emerged revealed themes about subjective neurological and physical effects, auditory and visual phenomena, impact on withdrawal and craving, and shifts in outlook on self and life.

Conclusion

Ibogaine treatment provides a subjectively powerful physiological, emotional, and psychological experience, attenuates opioid withdrawal, and results in a more optimistic outlook on self and life.

Open access
Journal of Behavioral Addictions
Authors:
Silvana Melissa Romero Saletti
,
Stephan Van den Broucke
,
Joël Billieux
,
Laurent Karila
,
Daria J. Kuss
,
José Manuel Rivera Espejo
,
Pavica Sheldon
,
Cathryne P. Lang
,
Melanie J. Zimmer-Gembeck
,
Palmyra Zollo
,
Clara Courboin
,
Dominica Diez
,
T. Phillip Madison
,
Jano Ramos-Diaz
,
César Augusto Eguia Elias
, and
Fiorella Otiniano

Abstract

Background and aims

Social network use is widespread, and the study of Instagram seems to have captured more attention in recent years. However, scale development and validation in the field has fallen short of providing sound scales of Instagram motives and usage patterns that consider the uniqueness of Instagram-related behavior. This paper describes the development, psychometric and cross-cultural validation of two new measurement instruments: the “Instagram Motives Questionnaire” (IMQ) and the “Instagram Uses and Patterns Questionnaire” (IUPQ).

Methods and results

A preliminary set of items was developed for each questionnaire based on a previous qualitative interview study on Instagram motives, uses, and consequences. In the first study, the questionnaires were distributed to a sample of 312 participants aged 18–35 years (M = 23.81; SD = 4.49), and an exploratory factor analysis was performed. A parsimonious and interpretable 6-factor solution that displayed adequate factor loadings and adequate Omega coefficients for both instruments were found. In a second study, the two instruments and other measures of known social network usage correlates and mental health consequences were administered online to 1,418 English-speaking participants aged 18–34 years (M = 21.35; SD = 3.89). Both scales showed good psychometric properties and the factor structure identified in study 1 was reproduced through confirmatory factor analysis. Omega reliability coefficients were adequate. Finally, when performing multi-group CFA along with a French (n = 1,826) and a Spanish (n = 3,040) sample, language and gender invariance were supported. Correlations with other relevant measures indicate good convergent validity of both scales.

Conclusions

The present research provides psychometrically sound instruments for further investigations on Instagram use behaviors.

Open access