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  • Author or Editor: A. Novak x
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In an exponentially growing wild-type fission yeast culture a size control mechanism ensures that mitosis is executed only if the cells have reached a critical size. However, there is some scattering both in cell length at birth (BL) and in cycle time (CT). By computational simulations we show here that this scattering cannot be explained solely by asymmetric cell division, therefore we assume that nuclear division is a stochastic, asymmetric process as well. We introduce an appropriate stochastic variable into a mathematical model and prove that this assumption is suitable to describe the CT vs. BL graph in a wild-type fission yeast population. In a double mutant of fission yeast (namely wee1-50 cdc25 D) this CT vs. BL plot is even more curious: cycle time splits into three different values resulting in three clusters in this coordinate system. We show here that it is possible to describe these quantized cycles by choosing the appropriate values of the key parameters of mitotic entry and exit and even more the clustered behavior may be simulated by applying a further stochastic parameter.

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Abstract

Introduction

The continuous collection, monitoring, and analysis of morbidity data enable health professionals to plan the capacity of the care system, to organise and optimise care, to measure the burden of diseases resulting from each morbidity, and to estimate its expected evolution.

Material and methods

In our study, we analyse the data of patient flow reports for the period 2011 to 2020 for the healing and preventive basic service defined as the basic task of the primary health care system (troop health service) of the Hungarian Defence Forces.

Results

Over 850,000 doctor-patient encounters over the ten-year period were mostly due to some form of acute care need, infection, and respiratory illness. The morbidity structure has not changed significantly over the period. In all cases, the top three were diseases of the respiratory system (J00-J99), diseases of the circulatory system (I00-I99), as well as musculoskeletal and connective tissue diseases (M00-M99). In 2020, the highest number of people with restrictions for health reasons in the period under review was 131 for diseases of the circulatory system and 179 for musculoskeletal disorders. In recent years, the time spent on medical leave or on sick leave has increased significantly in terms of the number of cases of incapacity to work.

Conclusions

Accurate knowledge of morbidity and health data can also provide the military leadership with important information on combat fitness, especially when the ever-increasing task load (mission activity, border tasks, Covid-19) has to be met by an armed corps selected from an ageing population.

Open access

The chemotaxis of human peripheral phagocytes, neutrophils and monocytes was examined in a strong static magnetic field (0.317±0.012 Tesla). The chemotaxis of the suspension of purified neutrophils and monocytes was tested in the Boyden chamber using C5a as a chemotactic signal. The chambers were placed into a temperature regulated (36.6 °C) equipment producing a strong static magnetic field (0.317 Tesla) for 60 minutes. The movement of cells proceeded into a nitrocellulose membrane toward the north-pole of the magnet, i.e. in the direction of the Earth's gravitational pull. The C5a induced chemotaxis of human neutrophils decreased significantly in the strong static magnetic field. Monocytes were not significantly effected. The strong static magnetic field decreased the chemotactic movement of neutrophils and this phenomenon may have implications when humans are exposed to magnetic resonance imaging for extended periods of time.

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