Authors:P. Oliveira, L. Bernardi, F. Murakami, C. Mendes, and M. Silva
Norfloxacin (NFX) is a synthetic antibacterial drug. The development of extended release tablets improves the patients’ comfort
and compliance, resulting in lower discontinuation of the therapy; with consequently decrease in bacterial resistance. In
the present work, the thermal behavior of NFX was investigated using TG and DSC techniques. Isothermal and non-isothermal
methods were employed to determine kinetic data of decomposition process. Compatibility studies between NFX and pharmaceutical
excipients, including three hydrophilic polymers were carried out in order to develop a new formulation of NFX to obtain extended
release tablets with an approved quality.
Authors:T. M. Milão, J. F. A. Oliveira, V. D. Araújo, and M. I. B. Bernardi
Zinc oxide is a widely used white inorganic pigment. Transition metal ions are used as chromophores and originate the ceramic pigments group. In this context, ZnO particles doped with Co, Fe, and V were synthesized by the polymeric precursors method, Pechini method. Differential scanning calorimetry (DSC) and thermogravimetry (TG) techniques were used to accurately characterize the distinct thermal events occurring during synthesis. The TG and DSC results revealed a series of decomposition temperatures due to different exothermal events, which were identified as H2O elimination, organic compounds degradation and phase formation. The samples were structurally characterized by X-Ray diffractometry revealing the formation of single phase, corresponding to the crystalline matrix of ZnO. The samples were optically characterized by diffuse reflectance measurements and colorimetric coordinates L*, a*, b* were calculated for the pigment powders. The pigment powders presented a variety of colors ranging from white (ZnO), green (Zn0.97Co0.03O), yellow (Zn0.97Fe0.03O), and beige (Zn0.97V0.03O).
Authors:L. Bernardi, P. Oliveira, F. Murakami, M. Silva, S. Borgmann, and S. Cardoso
The thermal analytical study of venlafaxine hydrochloride, a third generation antidepressant, was investigated using thermogravimetry
(TG) and differential scanning calorimetry (DSC). The DSC curves have shown a sharp endothermic event at 211 °C and TG demonstrated
a single stage of mass loss between 254 and 283 °C. Solid-state characterization was carried out by DRIFT, SEM, and XRPD demonstrating
the drug physicochemical properties including crystallinity. Drug-excipient compatibility studies investigated by DSC have
shown a possible physical interaction of the drug with magnesium stearate, microcrystalline cellulose and starch. Nevertheless,
these results where not confirmed by DRIFT and SEM analyses.
Authors:S. X. S. Costa, M. R. Galvão, D. P. Jacomassi, M. I. B. Bernardi, A. C. Hernandes, A. N. de Souza Rastelli, and M. F. Andrade
Thermal properties and degree of conversion (DC%) of two composite resins (microhybrid and nanocomposite) and two photo-activation methods (continuous and gradual) displayed by the light-emitting diode (LED) light-curing units (LCUs) were investigated in this study. Differential scanning calorimetry (DSC) thermal analysis technique was used to investigate the glass transition temperature (Tg) and degradation temperature. The DC% was determined by Fourier transform infrared spectroscopy (FT-IR). The results showed that the microhybrid composite resin presented the highest Tg and degradation temperature values, i.e., the best thermal stability. Gradual photo-activation methods showed higher or similar Tg and degradation temperature values when compared to continuous method. The Elipar Freelight 2TM LCU showed the lowest Tg values. With respect to the DC%, the photo-activation method did not influence the final conversion of composite resins. However, Elipar Freelight 2TM LCU and microhybrid resin showed the lowest DC% values. Thus, the presented results suggest that gradual method photo-activation with LED LCUs provides adequate degree of conversion without promoting changes in the polymer chain of composite resins. However, the thermal properties and final conversion of composite resins can be influenced by the kind of composite resin and LCU.