You are looking at 1 - 1 of 1 items for :
- Author or Editor: Jeffrey Santandrea x
- Chemistry and Chemical Engineering x
- Refine by Access: All Content x
The continuous-flow synthesis of a series of 11- to 26-membered macrocycles via copper-catalyzed azide-alkyne cycloaddition is reported. The approach employs homogeneous catalysis to promote formation of triazole-containing macrocycles in good to excellent yields (65–90%) at relatively high concentration (30–50 mM) using a phase separation strategy.