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Purpose

This study investigated the day-to-day variability of daily physical activity and its effect on sleep and mood in a longitudinal within-subjects study for 7 days and 6 nights.

Materials and methods

Healthy office employees aged 25–35 years with a sedentary lifestyle participated in the study. Seven-day sleep diaries were used to evaluate sleep patterns. Ten-point scales were used to measure the level of happiness and stress. Daily physical activity was measured in steps/day using pedometers. Two hundred forty-five steps/day scores and changes induced in sleep and mood were analysed.

Results

There is a relationship between daily physical activity and sleep/mood. An inverted U-shaped relationship may be assumed between sleep duration, sleep quality, feelings after waking up, and the number of steps/day. Increasing the number of steps/day decreases the level of stress and daytime sleepiness and increases sleep efficiency. Sleep efficiency/daytime sleepiness and sleep duration did not show any association.

Conclusions

Based on the results, after a physically exhausting day, decreased stress and improved sleep efficiency may be experienced, while sleep duration may decrease, which may reduce the participants’ motivation to develop an active lifestyle. For further studies, it would be crucial to use individual exercise intervention programmes to reinforce the positive effects of exercise on sleep and/or mood.

Open access

The teratogenic effects of lead acetate (Trial 1) and the possible teratogenic effect of this compound administered in combination with a fungicide containing 80% mancozeb (Trial 2) were studied in rats. The test substances were administered by gavage on Days 6-15 of gestation. In Trial 1, five groups were treated with lead acetate administered at doses of 0.1, 0.5, 1.0, 10.0 and 1000.0 mg/kg body weight (bwkg), respectively. In Trial 2, lead acetate was applied at doses of 0.1, 10.0 and 1000.0 mg/bwkg, respectively. In the latter case the dose of the pesticide was 750 mg/bwkg in all treated groups. Lead acetate was not teratogenic after a single administration. Combined administration of lead acetate and mancozeb gave rise to the following toxic effects: average maternal weight decreased during pregnancy, the ratio of live fetuses decreased after the two lowest doses, and fetal mortality increased in the lowest and in the highest dose groups. The ratio of fetal resorption was higher in all the treated groups than in the control group. A significant decrease occurred in average fetal and placental weight in each treated group as compared to the control. Maternal toxicity was expressed in paralysis of the hindlimbs in the two lowest dose groups. Maternal mortality was between 16.7 and 23.3% at the three dose levels. Phocomelia and hernia cerebri occurred as characteristic fetal developmental anomalies in all the treated groups. It is concluded that the joint administration of lead acetate and a mancozeb-containing fungicide can cause maternal toxicity, embryotoxicity and characteristic teratogenic effects.

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Restricted access
Interventional Medicine and Applied Science
Authors:
H. Vágó
,
P. Takács
,
A. Tóth
,
L. Gellér
,
Sz. Szilágyi
,
L. Molnár
,
V. Kutyifa
,
T. Simor
, and
Béla Merkely

Abstract

Cardiac electromechanical resynchronisation therapy (CRT) is an effective non-pharmacological treatment of patients suffering from drug refractory heart failure. However, approximately 20–30% of patients are non-responder. Cardiac magnetic resonance imaging (CMR) may play significant role in clarifying many questions in this patient population. Forty-five patients, suffering from severe drug refractory heart failure, underwent CMR before applying CRT. Left ventricular end-diastolic, end-systolic volumes, ejection fraction, myocardial mass, wall motion disturbances, localisation of non-viable myocardium were determined. Left ventricular dyssynchrony was determined by illustrating wall-time thickening in short-axis slices of left ventricle from basis to apex. CMR-proved underlying heart disease were postinfarction heart failure, dilated cardiomyopathy and non-compaction cardiomyopathy in 62, 27 and in 11%, respectively. Mean left ventricular ejection fraction was 24.5±10%, intraventricular dyssynchrony was 200±78 ms. In four patients, requiring surgical revascularisation after unsuccessful coronary sinus electrode implantation, optimal position for epicardial screw-in electrode was selected. According to the results of CMR, biventricular device was not implanted in 7 patients. During the follow-up of the 38 patients, 5 patients (13.16%) were non-responders, despite the approximately 22% non-responder ratio in our whole patient population treated by CRT but without performing previous CMR examination. In this patient population CMR may have a significant role in the selection of responder patient population.

Restricted access
Journal of Behavioral Addictions
Authors:
Orsolya Király
,
Mark D. Griffiths
,
Daniel L. King
,
Hae-Kook Lee
,
Seung-Yup Lee
,
Fanni Bányai
,
Ágnes Zsila
,
Zsofia K. Takacs
, and
Zsolt Demetrovics

Background and aims

Empirical research into problematic video game playing suggests that overuse might cause functional and psychological impairments for a minority of gamers. Therefore, the need for regulation in the case of video games (whether governmental or self-imposed) has arisen but has only been implemented in a few countries around the world, and predominantly in Asia. This paper provides a systematic review of current and potential policies addressing problematic gaming.

Methods

After conducting a systematic search in the areas of prevention, treatment, and policy measures relating to problematic Internet and video game use, papers were selected that targeted problematic gaming policies (N = 12; six in English and six in Korean). These papers served as the basis of this review.

Results

Policies were classified into three major groups: (i) policy measures limiting availability of video games (e.g., shutdown policy, fatigue system, and parental controls), (ii) measures aiming to reduce risk and harm (e.g., warning messages), and (iii) measures taken to provide help services for gamers. Beyond the attempt to classify the current and potential policy measures, the authors also tried to evaluate their efficiency theoretically and (if data were available) empirically.

Discussion and conclusions

Overall, it appears that although several steps have been taken to address problematic video game playing, most of these steps were not as effective as expected, or had not been evaluated empirically for efficacy. The reason for this may lie in the fact that the policies outlined only addressed or influenced specific aspects of the problem instead of using a more integrative approach.

Open access
Physiology International
Authors:
G. Molnár
,
V. A. Gyarmathy
,
J. Takács
,
S. Sándor
,
B. Kiss
,
J. Fazakas
, and
P. L. Kanizsai

Abstract

Objectives

Conditions that have similar initial presentations as sepsis may make early recognition of sepsis in an emergency room (ER) difficult. We investigated whether selected physiologic and metabolic parameters can be reliably used in the emergency department to differentiate sepsis from other disease states that mimic it, such as dehydration and stroke.

Methods

Loess regression on retrospective follow-up chart data of patients with sepsis-like symptoms (N = 664) aged 18+ in a large ER in Hungary was used to visualize/identify cutoff points for sepsis risk. A multivariate logistic regression model based on standard triage data was constructed with its corresponding receiver operating characteristic (ROC) curve and compared with another model constructed based on current sepsis guidelines.

Results

Age, bicarbonate, HR, lactate, pH, and body temperature had U, V, W, or reverse U-shaped associations with identifiable inflexion points, but the cutoff values we identified were slightly different from guideline cutoff values. In contrast to the guidelines, no inflexion points could be observed for the association of sepsis with SBP, DPB, MAP, and RR and therefore were treated as continuous variables. Compared to the guidelines-based model, the triage data-driven final model contained additional variables (age, pH, bicarbonate) and did not include lactate. The data-driven model identified about 85% of sepsis cases correctly, while the guidelines-based model identified only about 70% of sepsis cases correctly.

Conclusion

Our findings contribute to the growing body of evidence for the necessity of finding improved tools to identify sepsis at early time points, such as in the ER.

Open access
Orvosi Hetilap
Authors:
Zoltán Zsolt Nagy
,
Huba J. Kiss
,
Ágnes I. Takács
,
Kinga Kránitz
,
Cecília Czakó
,
Tamás Filkorn
,
Árpád Dunai
,
Gábor L. Sándor
, and
Illés Kovács

Bevezetés: A szürkehályog-műtétek eredményeinek javítására kifejlesztett femtolézer-asszisztált szürkehályog-műtétek tökéletesítésére nagy energiák összpontosulnak. Célkitűzés: A femtolézer-asszisztált szürkehályog-műtétek során alkalmazott új, 2.16-os vezérlőszoftverrel és a módosított kezelési maszkkal (SoftFit®) nyert tapasztalatok értékelése. Módszer: A 2.16-os szoftvert és az új kezelési maszkot 100 páciens 100 szemén alkalmazták femtolézer-asszisztált szürkehályog-műtétek során. Eredmények: A megújult rendszerrel a femtolézeres előkezelés 45–60 másodpercre csökkent. Az új kezelési maszk kisebb mérete könnyebb illesztést tett lehetővé akár gyermekszemen is. A maszkot rögzítő szívóerő 40–50 Hgmm-ről 16–20 Hgmm-re csökkent. A subconjunctivalis suffusio aránya 40%-ról 15–20%-ra csökkent, súlyossága mérséklődött. Szaruhártyaredők nem jelentkeztek, a szabadon lebegő capsulotomiák aránya 30%-ról 97%-ra nőtt. A lézerkezeléshez szükséges energia csaknem 50%-kal csökkent. A tervezettnek megfelelő cornealis sebek könnyen megnyithatóak és pontosan záródóak voltak. Következtetések: A SoftFit® kezelési maszk és az új szoftver a femtolézer-asszisztált szürkehályog-műtétek alkalmazási lehetőségeit bővítette, lehetővé téve a gyermekkori szürkehályog-műtétekben történő alkalmazást. A fejlesztések a módszer biztonságosságát és kiszámíthatóságát tovább növelték. Orv. Hetil., 2015, 156(6), 221–225.

Open access