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The mediator complexes transduce regulatory information from upstream regulatory elements to the transcription machinery in organisms ranging from yeasts to humans. By a genome-wide search we identified 14 ORFs and genes in the genome of the fission yeast Schizosaccharomyces pombe that encode putative homologues of  Saccharomyces cerevisiae mediator subunits. The Sch. pombe proteins are smaller and appear to form a mediator of lower complexity, which is consistent with the hypothesized ancient origin of fission yeasts.

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The orderSchizosaccharomycetalescontains a dimorphic and two yeast species.Sch. japonicuscan form both yeast cells and mycelium, depending on the substrate and the culturing conditions.Sch. pombeis a strictly unicellular organism, but it can be forced to form mycelial cell chains by inactivating members of thesepgene family. The mutations in most of thesepgenes confer pleitropic phenotypes indicating functional involvement in MAP-kinase-mediated signalling pathways. Two of them were found to encode transcription factor homologues of other eukaryotes.

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Acta Microbiologica et Immunologica Hungarica
Authors:
ZS. Antal
,
L. Manczinger
,
L. Kredics
,
Lajos Ferenczy
,
Zs. Benkő
,
M. Miskei
,
Cs. Fenyvesvölgyi
,
V. Benesoczki
, and
M. Sipiczki
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