Authors:Qi Zhanshun, Zhang Pilu, Wang Fangding, and Guo Jingru
The distribution of the chemical states of tellurium isotopes produced by252Cf spontaneous fission, collected separately in the matrixes of NaCl, Kl, NaF, CH3COONa·3H2O, Na2SO4 and NaNO3 crystals have been investigated. Two chemical states of tellurium isotopes maintained in these matrixes are Te(IV) and Te(VI). The relationships between the distribution of the chemical states of tellurium isotopes and the produced mode of tellurium, the chemical properties of collection matrixes, the time for collecting fission fragments are studied and the possible mechanism of the interactions of the fission products and the matrixes is discussed. The results show that the distribution of chemical states of tellurium isotopes depends on the chemical properties of the collection matrixes mainly.
Authors:Y. Zhao, C. Zhang, C. Qi, S. Feng, G. You, Z. Fu, F. Guo, and R. Wang
Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG2-Ade] and [9-N-(tritylmercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG3-Ade], are synthesized and labeled with 99mTc by directly labeling method. The stability of 99mTc-MAG2-adenine and 99mTc-MAG3-adenine in vitro is measured. The uptake radios of tumor to muscle at 3h post-injection are 5.70 and 4.92, respectively.
The biodistribution and scintigraphic imaging studies show that the two complexes have high localization in tumor and high
contrasted tumor images can be obtained, which suggest their potential utility as tumor imaging agents. But the high radioactivity
of abdomen could prevent the tumor imaging in this area.
Authors:C. Zhang, Y. Zhao, S. Feng, C. Qi, Z. Fu, F. Guo, and R. Wang
To increase the tumor uptake of Val-Gly-Gly (VGG), adenine was introduced into the peptide. N-mercaptoacetyl-VGG-adenine (MAVGG-adenine)
and MAVGG were labeled with 99mTc using a solution of SnCl2 and tartaric acid as reducing agent. Biodistribution in mice bearing the S180 tumor was measured and γ imaging was performed.
Compared with MAVGG, adenine conjugated MAVGG had higher tumor uptake and tumor to normal tissue ratios, which suggested that
the tumor uptake property of a peptide may be improved by introducing a nucleotide base. The high contrasted tumor images
of 99mTc-MAVGG-adenine also suggested its potential utility as tumor imaging agent.
Authors:Guan-Quan Wang, Ji Zhang, Shun-Zhong Luo, Na Wang, Hong-Yuan Wei, Wen-Jin Wang, Yu-Qing Yang, Guo-Ping Liu, and Xiao-Qi Yu
A new nitrido-188Re complex, 188ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution
in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2
carcinoma was grown in the livers of rabbits. Transcatheter arterial embolization (TAE) was performed using 188ReN-NEMPTDD/lipiodol solution. The SPECT images showed that the lipiodol solution could be concentrated in the tumor for about
12 hours. These results indicated that 188ReN-NEMPTDD/lipiodol could be a potential radiopharmaceutical for liver cancer.