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Accumulation of Angiotensin II (Ang II) in the kidneys of hypertensive rats infused chronically with Ang II occurs by AT1

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Acta Physiologica Hungarica
Authors:
Krisztina Szabadfi
,
P. Kiss
,
D. Reglodi
,
E. Fekete
,
A. Tamas
,
B. Danyadi
,
T. Atlasz
, and
R. Gabriel

Urocortin 2 (Ucn 2) is a corticotrop releasing factor paralog peptide with many physiological functions and it has widespread distribution. There are some data on the cytoprotective effects of Ucn 2, but less is known about its neuro- and retinoprotective actions. We have previously shown that Ucn 2 is protective in ischemia-induced retinal degeneration. The aim of the present study was to examine the protective potential of Ucn 2 in monosodium-glutamate (MSG)-induced retinal degeneration by routine histology and to investigate cell-type specific effects by immunohistochemistry. Rat pups received MSG applied on postnatal days 1, 5 and 9 and Ucn 2 was injected intravitreally into one eye. Retinas were processed for histology and immunocytochemistry after 3 weeks. Immunolabeling was determined for glial fibrillary acidic protein, vesicular glutamate transporter 1, protein kinase Cα, calbindin, parvalbumin and calretinin. Retinal tissue from animals treated with MSG showed severe degeneration compared to normal retinas, but intravitreal Ucn 2 treatment resulted in a retained retinal structure both at histological and neurochemical levels: distinct inner retinal layers and rescued inner retinal cells (different types of amacrine and rod bipolar cells) could be observed. These findings support the neuroprotective function of Ucn 2 in MSG-induced retinal degeneration.

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Journal of Behavioral Addictions
Authors:
Beáta Bőthe
,
Mónika Koós
,
Léna Nagy
,
Shane W. Kraus
,
Zsolt Demetrovics
,
Marc N. Potenza
,
Aurélie Michaud
,
Rafael Ballester-Arnal
,
Dominik Batthyány
,
Sophie Bergeron
,
Joël Billieux
,
Peer Briken
,
Julius Burkauskas
,
Georgina Cárdenas-López
,
Joana Carvalho
,
Jesús Castro-Calvo
,
Lijun Chen
,
Giacomo Ciocca
,
Ornella Corazza
,
Rita Csako
,
David P. Fernandez
,
Elaine F. Fernandez
,
Loïs Fournier
,
Hironobu Fujiwara
,
Johannes Fuss
,
Roman Gabrhelík
,
Ateret Gewirtz-Meydan
,
Biljana Gjoneska
,
Mateusz Gola
,
Joshua B. Grubbs
,
Hashim T. Hashim
,
Md. Saiful Islam
,
Mustafa Ismail
,
Martha C. Jiménez-Martínez
,
Tanja Jurin
,
Ondrej Kalina
,
Verena Klein
,
András Költő
,
Chih-Ting Lee
,
Sang-Kyu Lee
,
Karol Lewczuk
,
Chung-Ying Lin
,
Liverpool John Moores University's research team † Liverpool John Moores University's research team
,
Christine Lochner
,
Silvia López-Alvarado
,
Kateřina Lukavská
,
Percy Mayta-Tristán
,
Ionut Milea
,
Dan J. Miller
,
Oľga Orosová
,
Gábor Orosz
,
Sungkyunkwan University's research team †† Sungkyunkwan University's research team
,
Fernando P. Ponce
,
Gonzalo R. Quintana
,
Gabriel C. Quintero Garzola
,
Jano Ramos-Diaz
,
Kévin Rigaud
,
Ann Rousseau
,
Marco De Tubino Scanavino
,
Marion K. Schulmeyer
,
Pratap Sharan
,
Mami Shibata
,
Sheikh Shoib
,
Vera L. Sigre Leirós
,
Luke Sniewski
,
Ognen Spasovski
,
Vesta Steibliene
,
Dan J. Stein
,
Julian Strizek
,
Aleksandar Štulhofer
,
Berk C. Ünsal
, and
Marie-Pier Vaillancourt-Morel

Abstract

Background and aims

Despite its inclusion in the 11th revision of the International Classification of Diseases, there is a virtual paucity of high-quality scientific evidence about compulsive sexual behavior disorder (CSBD), especially in underrepresented and underserved populations. Therefore, we comprehensively examined CSBD across 42 countries, genders, and sexual orientations, and validated the original (CSBD-19) and short (CSBD-7) versions of the Compulsive Sexual Behavior Disorder Scale to provide standardized, state-of-the-art screening tools for research and clinical practice.

Method

Using data from the International Sex Survey (N = 82,243; M age = 32.39 years, SD = 12.52), we evaluated the psychometric properties of the CSBD-19 and CSBD-7 and compared CSBD across 42 countries, three genders, eight sexual orientations, and individuals with low vs. high risk of experiencing CSBD.

Results

A total of 4.8% of the participants were at high risk of experiencing CSBD. Country- and gender-based differences were observed, while no sexual-orientation-based differences were present in CSBD levels. Only 14% of individuals with CSBD have ever sought treatment for this disorder, with an additional 33% not having sought treatment because of various reasons. Both versions of the scale demonstrated excellent validity and reliability.

Discussion and conclusions

This study contributes to a better understanding of CSBD in underrepresented and underserved populations and facilitates its identification in diverse populations by providing freely accessible ICD-11-based screening tools in 26 languages. The findings may also serve as a crucial building block to stimulate research into evidence-based, culturally sensitive prevention and intervention strategies for CSBD that are currently missing from the literature.

Open access