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- Author or Editor: Yu. Norseev x
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Abstract
Investigation on electrophilic attaching of astatine-211 to methylene blue is carried out. Conditions for transferring astatine to a chemically active electrophilic form were found. A method for the production of astatine-211-tagged methylene blue has been developed. The resulting radiopharmaceutical preparation is free of the nonisotopic iodine carrier. The chromatographic method of purifying simultaneously the product by anion-exchange resin QAE-Sephades A-25 allows it to pass into a 0.9% solution of sodium chloride (physiological salt solution). The method provides the radiochemical yield of astatine-211-tagged methylene blue as large as 68±6%.
Abstract
The complex formation of astatine/I/ cation with diethylene triamine pentaacetic acid /DTPA/ and characterization of the complexes were investigated by electromigration in free electrolytes and by gel-chromatography on Sephadex G 25. We describe the conjugation procedure for the production of At-DTPA conjugated polyclonal antibodies.
Abstract
Dependence upon pH of Ac and Th distribution coefficients between the cation exchange resin and buffer citrate solutions had been investigated; the optimal conditions are suggested for effective separation of the elements in this system. These results are in successful accordance with such conditions calculated on the basement of Ac and Th citrate complex formation constants.The generator method for225 Ac periodical separation from229 Th samples is developed.229 Th storage in solution between separations excludes the contamination of actinium final solution with radiolysis products and provides 100-% yield of this isotope and its high radiochemical purity. The parent nuclide loss after continuous use of the generator does not take place.
