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Myocardial infarction is responsible for the majority of cardiovascular mortality and the pathogenesis of myocardial damage during and after the infarction involves reactive oxygen species. Serious efforts are under way to modulate the developing ischemia/reperfusion injury and recently the use of hydrogen sulfide (H2S) emerged as a new possibility. H2S has been best known for decades as a pungent toxic gas in contaminated environmental atmosphere, but it has now been recognized as a novel gasotransmitter in the central nervous and cardiovascular systems, similarly to nitric oxide (NO) and carbon monoxide (CO). This finding prompted the investigation of the potential of H2S as a cardioprotective agent and various in vitro and in vivo results demonstrate that H2S may be of value in cytoprotection during the evolution of myocardial infarction. Although several questions remain to be elucidated about the properties of this new gasotransmitter, increased H2S levels may have therapeutic potential in clinical settings in which ischemia/reperfusion injury is encountered. This review article overviews the current understanding of the effects of this exciting molecule in the setting of myocardial ischemia/reperfusion.
D. R. Nielsen and O. Wendroth. 2003. Spatial and Temporal Statistics. sampling Field Soil and their Vegetation. Castena Verlag, Reiskirchen, Germany. 416 pages, many illustrations. Paperback. ISBN 3-923381-46-6. Price: 50 EUR. Y. Gutterman. 2002. Survival Strategies of Annual Desert Plants (Adaptations of Desert Organisms). xx + 348 pages. Springer-Verlag, Belin, Heidelberg, New York. Hardcover. ISBN: 3-540-43172-1. Price: 159 EUR. P. S. Johnson, S. R. Shifley and R. Rogers. 2002. The Ecology and Silviculture of Oak. CABI Publishing, Wallingford, UK. 503 pages. Hardback. ISBN 0 85199 570 5. Price: 85 GBP, 149 USD. J. Belnap and O.L. Lange (eds.). 2003. Biological Soil Crusts: Structure, Function and Management (Ecological Studies, Vol. 150). 1st edition, revised 2nd printing. xviii + 503 pages. Springer-Verlag, Berlin, Heidelberg, New York. Softcover. ISBN: 3-540-43757-6. Price: 49.95 EUR.