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enhance prothrombotic pathways by stimulating endothelial cells to expose tissue factor. EOS, platelet, and endothelium interplay are crucial for thrombus formation. EOS promotes platelets and vasculature to proadhesive and prothrombotic phenotype [ 4
cerebral blood flow becomes compromised during aging ( 59 ). The endothelium is an actively involved component of the neurovascular unit, which plays a crucial role in propagation of vasodilation during functional hyperemia. NO released from the cerebral
the inflamed endothelium where they differentiate into macrophage phenotypes with highly phagocytic ability. They can scavenge modified low-density lipoprotein (mLDL) and eventually form foam cells, which along with other immune cells can increase
tissues and organs. Prostacyclin [prostaglandin 12 (PGI2)], which is synthesized by the vascular endothelium, is a potent vasodilator, inhibits the aggregation of platelets in vitro and has cytoprotective effect on body tissues and organs ( 7 ). IL is a
). Blacher et al. ( 4 ) found that every 1 m/s elevation of PWV increased the CV and total mortality by 14% in ESRD. Recently, Nowak et al. ( 40 ) reported that impaired endothelium-dependent vasodilation and enhanced arterial stiffness were independent
prostacyclin (PGI2) have a vasodilator effect; endothelin-1 (ET-1) and platelet-activation factor (PAF) are vasoconstrictor molecules. All of them are important regulative modulators of the endothelium and have a very important role in vasoconstrictor and
199 207 . 105. I. V. Poliachenko 2010 Ultrastructural changes of vascular endothelium in patients with chronic
examination of samples. But a significant number of sinusoids represented by one layer of endothelium, with almost complete lack of basal membrane, can be seen only when using additional methods of tissue staining (Fig. 3 ) . The total area occupied by a
(a structural element of the BBB that serves as an anchor of the endothelium) ( 45 ). A single human hippocampal astrocyte may associate with approximately two million synapses ( 48 ). Astrocyte enwrapping may play a critical role in memory
SM , Bhunia AK , et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels . Circ