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VLD (Figure 1 ) individually or in combination with other drugs in fixed dose pharmaceutical formulations, while a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method is presented for both the drugs in combination [ 7 ], but no stability

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spectroscopy (LC–MS/MS) overcomes matrix background interference and improves signal-to-noise ratio, so it is more sensitive to complex biological samples and more suitable for analysis of low-level components. The purpose of this study was to develop

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. ; Uttam , B. ; Tapas , C. ; Tapan , P. ; Simultaneous determination of tamsulosin and dutasteride in human plasma by LC-MS-MS , J. Chromatogr. 2008 , 67 , 893 – 903 . 10.1365/s10337-008-0613-7 9

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of organic solvents [ 7 ]. Fu et al. (2019) developed a method by UE and LC-MS/MS analysis, which took 37 min and consumed more than 17 mL of organic solvents [ 10 ]. Song et al. (2013) developed a method by UE and LC-TOF/MS. It consumed 9 mL of

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Acta Chromatographica
Authors:
Qishun Liang
,
Tianyu Chen
,
Lvqi Luo
,
Yizhe Ma
,
Congcong Wen
, and
Xueli Huang

curdione can inhibit thrombin-induced platelet activation and aggregation [ 9 ]. There were several LC-MS or LC-MS/MS methods developed for determination of curdione in rat or rabbit plasma [ 19–24 ], however, no UPLC-MS/MS method developed for

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selectivity, high sensitivity, and can provide relative molecular weight and structural information, especially for complex samples [ 18–20 ]. Therefore, it is currently the main method used for drug detection in biological samples. McKinney developed a LC-MS/MS

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detecting technique such as the chromatography tandem mass spectrometry (LC–MS/MS) method or ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOFMS). Beyond this, we utilize a rapid, precise, effective method of

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H : HPLC and LC-MS/MS methods for determination of sodium benzoate and potassium sorbate in food and beverages: performances of local accredited laboratories via proficiency tests in Turkey . Food Chem. 175, 273 – 279

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concentration-time curve of mice after intravenous (iv, 5 mg kg −1 ) and intragastric (ig, 15 mg kg −1 ) administration of pancratistatin in mice Conclusion In this work, we established a rapid, exclusive and accurate LC-MS/MS method for the determination of

Open access
European Journal of Microbiology and Immunology
Authors:
Markus Krohn
,
Thomas Wanek
,
Marie-Claude Menet
,
Andreas Noack
,
Xavier Declèves
,
Oliver Langer
,
Wolfgang Löscher
, and
Jens Pahnke

protocol for quantitative targeted absolute proteomics (QTAP) by LC–MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood–brain barrier in ddY, FVB, and C57BL/6J

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