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4,490.3 1.89 – 6 h 4,450.8 1.82 – 24 h 4,400.1 1.94 0.19 3 days 3,410.6 5.54 5.33 7 days 3,001.3 6.88 5.45 Caffeine 30 min 6,900.5 1.75 – 6 h 6,910.2 1.85 – 24 h 6,942.2 1.66 0.115 3 days 6,805.1 3.99 7.56 7 days 6,700.9 5.34 6.22 Phenylepherine 30

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another NH proton at position 5. This suggested confirming the presence of one NH and one NH2 group in the molecule. The presence of nOe cross-correlations between H1/H10, H3/H5, H6/H16, H12/H18, and H13/H18 along with the HMBC correlations between H18/C17

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leaves. The laxative, wound healing, antioxidant, anti-inflammatory, immunostimulant, antimicrobial, antitumor, analgesic and neuroprotective effects of A. vera plant have been reported [ 3–7 ]. Allantoin is a chemical compound with formula C 4 H 6 N 4

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. Nobiletin and tangeretin were administered intravenously (iv) 1 mg kg −1 and orally (po) 5 mg kg −1 , respectively, with 6 rats in each group, for a total of 24 rats. At 0.083 3, 0.5, 1, 2, 3, 4 h, 6, 8 and 12 h time points, 0.3 mL blood was collected from

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1/2 z h 6.2 ± 2.0 7.0 ± 5.9 CL z/F L/h/kg 2.9 ± 0.5 35.1 ± 12

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Acta Chromatographica
Authors:
Qinghua Weng
,
Lianguo Chen
,
Luxin Ye
,
Xiaojie Lu
,
Zheng Yu
,
Congcong Wen
,
Yichuan Chen
, and
Gang Huang

2.5 ± 1.4 7.8 ± 3.5 t 1/2 z h 6.2 ± 4.8 6.7 ± 3

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.128 ± 0.4 4.3 MRT (0-∞) h 9.316 ± 0.55 5.9 t 1/2 z h 4.149 ± 0.92 22.2 T max h 6 ± 0 0 Vz/F L kg −1 2.797 ± 0.64 22.9 CLz/F L h −1 kg −1 0.468 ± 0.05 10.5 C max ug L −1 1,879.1 ± 340.72 18.1 Conclusion A reliable and high-throughput UPLC-MS/MS method was

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Acta Chromatographica
Authors:
Yangfan Du
,
Shunjun Ma
,
Dizhong Chen
,
Runrun Wang
,
Xianqin Wang
,
Congcong Wen
, and
Xiuwei Shen

-BUTINACA after oral administration ( n = 6) Parameters Unit Oral AUC (0-t) ng mL −1 *h 2923.0 ± 523.5 AUC (0-∞) ng mL −1 *h 3004.2 ± 570.4 MRT (0-t) h 6.3 ± 0.7 MRT (0-∞) h 7.1 ± 0.8 t 1/2z h 4.4 ± 1.1 T max h 2.8 ± 0.5 C max ng mL −1 616.9 ± 154.5 AUC (0-t

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and noscapine in rat plasma are shown in Fig. 3 . The half-lives ( t 1/2z ) of papaverine and noscapine in the rats after intravenous administration were 1.0 ± 0.2 h, 6.2 ± 2.2 h, respectively, while the t 1/2z after oral administration were 2.4 ± 0

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