Authors:Meifei Lu, Xiaojie Lu, Zheng Yu, and Congcong Wen
significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium. Pharmacokinetics is a discipline that quantitatively studies the laws of drug
pharmacology of hapepunine, it was necessary to investigate its pharmacokinetics. Pharmacokinetic study was a discipline that quantitatively investigates the absorption, distribution, metabolism, and excretion of drugs in vivo [ 6 , 7 ]. Therefore, it was
Authors:Aixia Han, Guanyang Lin, Jinzhang Cai, Qing Wu, Peiwu Geng, Jianshe Ma, Xianqin Wang, and Chongliang Lin
, corynantheine, and dihydrogen coinine [ 8 , 9 ].
The study of pharmacokinetics quantitatively investigates the absorption, distribution, metabolism, and excretion (ADME) of drugs in vivo, as well as the underlying mechanism, interaction within complex
Authors:Abdullah Altayban, Mahmoud Kandeel, Yukio Kitade, and Mohammed Al-Nazawi
; Bachmann et al . , 2018 ), endometritis ( Amiridis et al . , 2003 ), respiratory infections ( Funaki et al . , 2001 ), and septicaemia ( Thomas et al . , 2004 ). The pharmacokinetics of cefquinome were previously estimated in sheep ( Corum et al . , 2019
[ 9–20 ]. Compared to HPLC and LC-MS/MS, UPLC-MS/MS is faster, possessing significant advantages in the investigation on pharmacokinetics of drugs [ 21–28 ]. Meanwhile, the powerful separation and analysis capacity is applicable to analyze the in vivo
mg/kg) [ 23 ]. However, the retention time of psoralidin in two methods is more than 14 min, and there is no pharmacokinetic report after intragastric administration of psoralidin. In fact, as for traditional Chinese medicines (TCMs), it is of more
Authors:JianHua Zhang, Ling Wang, Xi Zhu, Xue Bai, and Hua Yin
representative bioactive compounds of Fuzi, are directly related to the pharmacological effects and toxicological effects of YGY in vivo.
Pharmacokinetic (PK) studies are useful to elucidate and predict the efficacy and toxicity of drugs and helpful in
Authors:Peiwu Geng, Xinhua Luo, Xiufa Peng, Zixia Lin, Wenhao Chen, Jin Zhang, Congcong Wen, Lufeng Hu, and Siyi Hu
/reperfusion-induced delayed neuronal damage in mice [ 10 ]. With so many great effects, it shows promising application. However, further research is still in need to confirm the relative effectiveness and achieve the pharmacokinetic characteristics of eupatilin.
Authors:Genquan Yan, Lu Yu, Xu Chen, Triet Tran, Lam Nguyen, Zhijun Wang, and Ling Wang
these diseases [ 13 ]. The trade name for apremilast is Otezla, and it is manufactured by Celgene Corporation (Summit, NJ, USA) as 10-mg, 20-mg, and 30-mg tablets [ 14 ]. As a new oral drug, a pharmacokinetic study is required to describe its disposition