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Abstract

Psychedelic substances such as psilocybin and ketamine may represent the future of antidepressant treatment, due to their rapid and prolonged effects on mood and cognition. The current body of psychedelic research has focused on administration and treatment within a psychiatric context. Here, instead, we put to the test the contention that it is necessary to evaluate the current state of this literature from a broader biopsychosocial perspective. Examining these arguably neglected social and psychological aspects of psychedelic treatment can provide a more holistic understanding of the interplay between the interconnected domains. This review of six major clinical trials applies a biopsychosocial model to evaluate the antidepressant effects of psilocybin and ketamine assisted therapy. We conclude that combination psychedelic treatment and psychotherapy facilitate more enduring and profound antidepressant effects than produced by ketamine or psilocybin alone. Emphasising the advantages of therapeutic intervention will encourage those who may attempt to self-medicate with psychedelics to instead seek a framework of psychological support, minimising associated risks of unregulated use.

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Abstract

Background and aims

This scoping review employed a multifaceted conceptualization of well-being to examine how psilocybin use affects well-being and related sub-concepts in healthy individuals. It investigated which factors influence the relationship between psilocybin use and well-being, what research protocols have been employed, and what underlying mechanisms have been proposed in existing studies.

Methods

A comprehensive literature search in line with the PRISMA guidelines was conducted. Scopus, PubMed, PsycINFO, Web of Science, and Google Scholar were searched for peer-reviewed articles about psilocybin and well-being in healthy populations.

Results

Studies were heterogeneous in regard to study objectives, study design, study procedure, sample size and psilocybin dosage. In all studies, psilocybin use led to positive well-being-related outcomes for the majority of participants. Facets of well-being positively affected by psilocybin use in this review were self-acceptance, positive relationships, and meaning/purpose in life.

Conclusions

This scoping review provided preliminary evidence for the beneficial effects of psilocybin on well-being and related sub-concepts such as self-acceptance, positive relationships, and meaning/purpose in life in healthy individuals. Ego-dissolution, unity, connectedness, and mystical-type experiences are interrelated concepts that seem to be crucial for explaining such positive well-being-related effects of psilocybin. Under conducive conditions, the use of psilocybin may contribute to healthy functioning, through broad and sustained improvements in a variety of well-being concepts. Due to the heterogeneous nature of the studies, more definite conclusions require further research with a rigorous and homogeneous design.

Open access

Abstract

Objective

Engaging in practices of intimacy meant to develop and sustain intimacy can be beneficial for couples. Psychoactive substances such as 3,4-Methylenedioxymethamphetamine (MDMA) have shown to facilitate bonding within couples and it is hypothesised that classic psychedelics, due to their property to increase prosocial behaviours, can similarly promote interactional intimacy. This study explores shared experiences of altered states of consciousness within romantic couples and their impact on intimacy in relationships.

Participants

Twelve participants (six couples) between 19 and 29 years of age who had used psychedelics with their current partner were recruited.

Method

Qualitative data was gathered via simultaneous interviews with both members of a couple. The semi-structured interviews featured an in-depth exploration of multiple shared psychedelic experiences. Reflexive thematic analysis was employed to analyse the resulting transcripts.

Results

Three themes with subsequent subthemes were identified, portraying couples' experiences during psychedelic-induced altered states of consciousness: navigating anxiety (subthemes: novelty, preparation, shifting environment, and calming presence), reshaping practices (subthemes: excessive worrying, spirited discussions, and straight talking), and encountering bliss (subthemes: meeting the unexpected, the beauty around us, leaving the everyday behind, and breaking through).

Conclusions

Couples' experiences with classic psychedelics align with criteria for interactional intimacy (i.e., self-exposure, positive involvement, and shared understanding), but their distinct nature warrants a novel definition of psychedelic intimacy. The unique pair bonding during shared psychedelic experiences could be utilized by psychedelic-assisted couples therapy.

Open access

psychedelics and technical innovation as “technologies of consciousness” (Fred Turner), showing how authors, artists, and intellectuals considered psychedelics and advancements like the computer and the videotape as cultural analogues: “tools that could deliver

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Psychedelics and critical theory

A response to Hauskeller's individualization and alienation in psychedelic psychotherapy

Journal of Psychedelic Studies
Authors:
Julien Tempone-Wiltshire
and
Tra-ill Dowie

-ecology and nature-connection; Indigenous ritual and ceremonial practices; and Eastern contemplative technologies. Each of these domains have in recent years been drawn into the ‘therapeutic’ fold, and may be understood in relation to the expansion of advanced

Open access

taken up by conservative public personalities, the corporate-psychedelic subculture, and neo-Nazi organisations: as technologies for justifying hierarchy-based, conservative ideologies and reinforcing capitalist systems of alienation. We are sympathetic

Open access
Journal of Psychedelic Studies
Authors:
Neşe Devenot
,
Brian A. Pace
,
Jason Slot
, and
Alan K. Davis

-assisted therapy (P-AT), respectively. In this Special Issue, we share selected perspectives from and inspired by Psychedemia, 2022 in the spirit of interdisciplinary scholarship: Emma Stamm —now an Assistant Professor of Science, Technology, and Society (STS) at

Open access

, hallucinatory character of Silicon Valley's self-serving narratives. Far from the promise of healing trauma, the alternative would amount to both fields' complicity in the use of AI and psychedelics as technologies of elite persuasion. Elite hallucinations in AI

Open access

about the role of localized social networks in non-indigenous contexts. In this context, local is either based in geographic proximity or in chosen communities of users brought together through communication technology, such as the internet. The

Open access