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ADB-BUTINACA have not been reported. UPLC-MS/MS technology features fast analysis speed, high detection sensitivity and strong anti-interference ability. Therefore, the aim of this study was to develop a rapid, sensitive and reliable UPLC-MS/MS method
conventional analytical techniques, ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC–MS/MS) is documented to possess improved sensitivity, selectivity, and specificity in quantitative determination of the active compound of
reported. Compared with capillary-zone electrophoresis, HPLC, and LC–MS, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was more sensitive, high throughput, and time saving [ 16 – 20 ]. In this study
sarecycline (A) and poziotinib (B, IS) To date, few literatures have involved analytical methods for the detection of sarecycline in rat plasma, especially the sarecycline on rat about bioavailability. A UPLC-MS/MS (chromatography-tandem mass spectrometry of
has been published. Here, a rapid and simple UPLC–MS/MS method was established for determination of byakangelicol in rat plasma. The pharmacokinetics of byakangelicol after oral (PO) and intravenous (IV) administration was studied
[ 9–20 ]. Compared to HPLC and LC-MS/MS, UPLC-MS/MS is faster, possessing significant advantages in the investigation on pharmacokinetics of drugs [ 21–28 ]. Meanwhile, the powerful separation and analysis capacity is applicable to analyze the in vivo
long runtime, and the selective ion monitoring (SIM) mode was used to quantify isocorynoxeine in rat plasma in their study. In this study, we presented a fast and sensitive UPLC–MS/MS method for isocorynoxeine in rat plasma in the multiple
, distribution, and metabolism, and the bioavailability was greatly improved. Ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) combined technology combines the high resolution of liquid chromatography with the high
designed to measure the concentration of tectorigenin, in rat blood plasma and study their pharmacokinetics after administration. Yang et al. developed a simple, reliable, and sensitive UPLC-MC/MS method to analyze the pharmacokinetic profiles of Iris
–MS/MS, ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) is more sensitive [ 10 ], possessing significant advantages in pharmacokinetic investigations of chemical drugs. The superior separation and analysis capacity is ideal for
