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Acta Chromatographica
Authors:
Peiwu Geng
,
Jing Zhang
,
Bingbao Chen
,
Qianqian Wang
,
Shuanghu Wang
, and
Congcong Wen

conventional analytical techniques, ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC–MS/MS) is documented to possess improved sensitivity, selectivity, and specificity in quantitative determination of the active compound of

Open access
Acta Chromatographica
Authors:
Qinghua Weng
,
Lianguo Chen
,
Luxin Ye
,
Xiaojie Lu
,
Zheng Yu
,
Congcong Wen
,
Yichuan Chen
, and
Gang Huang

reported. Compared with capillary-zone electrophoresis, HPLC, and LC–MS, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was more sensitive, high throughput, and time saving [ 16 – 20 ]. In this study

Open access
Acta Chromatographica
Authors:
Yonghui Shen
,
Deru Meng
,
Feifei Chen
,
Hui Jiang
,
Liming Hu
,
Yunfang Zhou
, and
Miaomiao Zhang

sarecycline (A) and poziotinib (B, IS) To date, few literatures have involved analytical methods for the detection of sarecycline in rat plasma, especially the sarecycline on rat about bioavailability. A UPLC-MS/MS (chromatography-tandem mass spectrometry of

Open access
Acta Chromatographica
Authors:
Xi Bao
,
Bingge Huang
,
Yiting Mao
,
Zhiguang Zhang
,
Yunfang Zhou
,
Congcong Wen
, and
Quan Zhou

has been published. Here, a rapid and simple UPLC–MS/MS method was established for determination of byakangelicol in rat plasma. The pharmacokinetics of byakangelicol after oral (PO) and intravenous (IV) administration was studied

Open access

[ 9–20 ]. Compared to HPLC and LC-MS/MS, UPLC-MS/MS is faster, possessing significant advantages in the investigation on pharmacokinetics of drugs [ 21–28 ]. Meanwhile, the powerful separation and analysis capacity is applicable to analyze the in vivo

Open access

long runtime, and the selective ion monitoring (SIM) mode was used to quantify isocorynoxeine in rat plasma in their study. In this study, we presented a fast and sensitive UPLC–MS/MS method for isocorynoxeine in rat plasma in the multiple

Open access
Acta Chromatographica
Authors:
Jianbo Li
,
Zheng Yu
,
Cheng Han
,
Zhening Wang
,
Yujie Hu
,
Congcong Wen
, and
Chongliang Lin

, distribution, and metabolism, and the bioavailability was greatly improved. Ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) combined technology combines the high resolution of liquid chromatography with the high

Open access

designed to measure the concentration of tectorigenin, in rat blood plasma and study their pharmacokinetics after administration. Yang et al. developed a simple, reliable, and sensitive UPLC-MC/MS method to analyze the pharmacokinetic profiles of Iris

Open access
Acta Chromatographica
Authors:
Shanjiang Chen
,
Miaoling Huang
,
Zheng Yu
,
Jiamin He
,
Binge Huang
,
Xianqin Wang
,
Jianshe Ma
, and
Congcong Wen

–MS/MS, ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) is more sensitive [ 10 ], possessing significant advantages in pharmacokinetic investigations of chemical drugs. The superior separation and analysis capacity is ideal for

Open access
Acta Chromatographica
Authors:
Qishun Liang
,
Tianyu Chen
,
Lvqi Luo
,
Yizhe Ma
,
Congcong Wen
, and
Xueli Huang

curdione can inhibit thrombin-induced platelet activation and aggregation [ 9 ]. There were several LC-MS or LC-MS/MS methods developed for determination of curdione in rat or rabbit plasma [ 19–24 ], however, no UPLC-MS/MS method developed for

Open access