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Lakatta, E. G., Levy, D.: Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part I: Aging arteries: a “set up” for vascular disease. Circulation, 2003, 107
During the aging process of mammals first a phase of obesity and increased adiposity is observed in middle-aged subjects, then anorexia and loss of body weight (sarcopenia) at old age. A possible agedependence of the anorexigenic alpha-melanocyte-stimulating-hormone (alpha-MSH) in these regulatory changes was studied. Male Wistar rats aged 6–8 weeks (juvenile), 3–4 months (young adult), 6 and 12 months (middle-aged), and 24–26 months (old) were equipped with chronic cannula to the lateral cerebral ventricle. The effect of 5 μg alpha-MSH injected through the cannula was analyzed on food intake evoked by 24-h food deprivation. Juvenile rats seemed almost resistant to alpha-MSH (21.9% suppression). In young adults alpha-MSH suppressed food intake by 68.7%. However, the alpha-MSH-induced anorexia was significantly less pronounced in middle-aged (55.7% or 26.4% in rats aged 6 or 12 months, respectively), and much more pronounced (73.3%) in old rats. The adiposity (judged by the relative amount of perirenal fat) increased until middle-age, but did not change between middle-age and old-age. It is concluded that changes in alpha-MSH responsiveness possibly contribute to both the age-related obesity in middle-aged rats and to the anorexia of old ones: first the adiposity then the age may be the important factor.
References 1. E.G. Lakatta D. Levy 2003 Arterial and cardiac aging: major
Graham, S.: Old age was secret of modern humans’ success. Scientific American, 2004, 291 , 115–116. Graham S. Old age was
study on ageing, and one was a cross-sectional study. The included studies cover areas of three continents (Europe, Asia, and North America) ( Fig. 2 ). The samples of most studies come from the population of older adults (aged older than 55 years
older people . Age Ageing 39 , 412 – 423 ( 2010 ) 10.1093/ageing/afq034 2. Park , SW , Goodpaster , BH
Foreword Dear Reader, This issue of Developments in Health Sciences is dedicated to the topics of ageing humans and ageing societies. We think that these topics are very important and relevant because
age until about 70 years of age with some decrease in the oldest old probably due to healthy survival bias [ 3 ]. As a consequence of continuously increasing life expectancy in the last decades, the proportion of elderly people is becoming higher and
Society for Maternal-Fetal Medicine.) Obstet. Gynecol., 2013, 121 (5), 1122–1133. Gardosi, J., Francis, A.: Adverse pregnancy outcome and association with small for gestational age birthweight by customized and
Klein, R., Peto, T., Bird, A. és mtsai: The epidemiology of age-related macular degeneration. Am. J. Ophthalmol., 2004, 137 , 486–495. Bird A. The epidemiology of age
