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Abstract
Isothermal microcalorimetry was used to evaluate excipient compatibility of solid dosage form. Oxybutynin hydrochloride and cefaclor were used as model drugs for compatibility test with excipients. The calorimetric data for compatibility test were compared with those of HPLC data. Evaluation of compatibility between drug and excipient of solid dosage form might be possible to use isothermal microcalorimetry instead of conventional method. By using microcalorimetric method, the evaluation of the compatibility between drug and excipient could be successfully performed with a simple operation in a short time. The application of the isothermal microcalorimetry would be useful for the screening test of the drug compatibility with excipients.
extraordinary low heating rates employed in the whole experiments effect the decomposition of CL-20. Compared with the DSC data, the peaks of the CL-20/CMDB propellant obtained by microcalorimetry is much lower. This may be attributed to the airtight environment
the interaction between the surface site and the probe molecule. Adsorption microcalorimetry is a direct, reliable technique for the investigation of the acid–base features of solids [ 9 – 13 ]. By the simultaneous assessment of the adsorbed amount of
The applications of microcalorimetry techniques to biomolecular systems have expanded in recent years with the increasing availability of sensitive calorimeters suitable for the study of stability and interactions of biological macromolecules
microcalorimetry to evaluate kinetic and energetic parameters of Cr(VI) sorption on fish scales. Real time monitoring immersion microcalorimetry, being a direct reaction investigation method, may, therefore, be of specific advantage in the study of specific
Abstract
A brief survey is given of recent developments and current activities in isothermal microcalorimetry. The discussion focuses on new methods in areas where the techniques have proved to be particularly useful or are promising to be so, in a near perspective. Some problems and limitations with current methods are also discussed.
-producing reactions. Using a sensitive calorimeter, the heat-producing and cell growth progress can be recorded. Further, to find the activity of other materials in the cell growth, microcalorimetry is a very useful tool for performing fundamental studies of the
Toxic effects of protoberberine alkaloids from Rhizoma Coptidis on Tetrahymena thermophila BF5 growth based on microcalorimetry
A reliable evaluation method of structure–function relationship
curves of living cells are obtained, which reflects the information of the metabolic processes [ 1 , 2 ]. Microcalorimetry can be employed to directly determine the biological activity of a living system and provide continuous measurement of heat
