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curdione can inhibit thrombin-induced platelet activation and aggregation [ 9 ]. There were several LC-MS or LC-MS/MS methods developed for determination of curdione in rat or rabbit plasma [ 19–24 ], however, no UPLC-MS/MS method developed for
determination of narciclasine in serum, with the retention time of narciclasine was 5 min, and needed 0.5 mL blood for the sample preparation [ 16 ]. Until now, there were no reports about the pharmacokinetics of narciclasine in biological fluids by UPLC
, phenolic compounds were analyzed by a sensitive and selective ultra-performance liquid chromatography combined with photodiode-array detector–electrospray ion source–mass spectrometry (UPLC–PDA–ESI–MS) method in wheat varieties and their antioxidant
-MS/MS [ 16 ]. Another method, UPLC-MS/MS, has high sensitivity and good selectivity. So far, there have been several reports on the detection of carbofuran and its metabolite, 3-hydroxycarbofuran in vivo or in vitro [ 10, 17–20 ]. However, to our best
drug can be more comprehensively characterized. Compared to conventional analytical methods (HPLC and HPLC-MS), UPLC-MS/MS stands out as a highly sensitive and reliable technique that integrates the separation efficiency of UPLC with the structural
isocratic mobile phase consisting of acetonitrile–water–formic acid (75:25:0.1, v / v ). The ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method that we developed focused on the analytical ability for ligustroflavone in rat
same condition. Spiked fish samples were prepared by adding the proper amounts of standard solutions. LC-MS/MS analysis The analysis was performed on a Waters ACQUITY UPLC H-Class system (Waters, Milford
[ 17 ]. In this work, a method based on ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was established for the determination of modafinil in the plasma of rats, and its pharmacokinetics were studied under different
simple hair extraction, followed by ultra-performance liquid chromatography–tandem mass spectroscopy (UPLC–MS/MS) analysis. The main metabolite of methamphetamine was amphetamine; the main metabolites of heroin were morphine and monoacetylmorphine; the
, Germany). Ultra-pure water was prepared by Millipore Milli-Q purification system (Bedford, MA, USA). Instrumentation and Conditions Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) with
