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, 11956 – 11968 . 3. For reviews on flow chemistry under high-T/p conditions, see: (a) Hessel , V. ; Kralisch , D. ; Krtschil , U. Energy Environ

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application of flow chemistry for multistep organic synthesis, see: (a) Wegner, J.; Ceylan, S.; Kirschning, A. Adv. Synth. Catal. 2012 , 354 , 17–57; (b) Baumann, M.; Baxendale, I. R.; Ley, S. V. Mol. Divers . 2011 , 3 , 613–630. For some recent

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Production of quinaldine and derivatives is proposed using sulfuric acid as commercial homogeneous acid catalyst in water in continuous flow chemistry. This approach is a rapid, practical and green route for the synthesis of 2-methylquinolines and permit to obtain the target compounds in 39–91% yields.

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Journal of Flow Chemistry
Authors:
Alastair Baker
,
Michael Graz
,
Robert Saunders
,
Gareth J. S. Evans
,
Sandra Kaul
, and
Thomas Wirth

Abstract

Using mild conditions and short reaction times, symmetrical disulfides have been synthesized in flow chemistry using phase transfer catalysts to facilitate the substitution of organohalides with disodium disulfide. Also, the synthesis of symmetrical trisulfides was possible using this procedure with an additional equivalent of sulfur.

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This paper describes the selective and reproducible debenzylation of benzyloxypyrazinones using flow chemistry to yield N-hydroxypyrazinones. Flow methodology enabled us to avoid overreduction of the compounds to pyrazin-2(1H)-ones.

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Deuterated compounds are important in drug discovery and development, e.g., to prepare the so-called stable isotopically labeled internal standards. However, their preparation can be challenging, and its scalability could be difficult with regard to safety aspects. Herein, we report the first continuous-flow iridium(I)-catalyzed ortho-directed hydrogen–deuterium exchange reaction in microreactors. An immobilized iridium(I) catalyst was loaded in continuous-flow microreactors, such as continuous stirred tank reactors and packed-bed reactors. Best results were obtained in a packed-bed reactor allowing deuterium labeling up to M +7.

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9-Hydroxymethylxanthene derivatives were optimized as a photolabile protecting group for amines in flow chemistry. 9-Methylxanthene and 2-methoxy-9-methylxanthene showed excellent deprotection yields in protic and aprotic solvents, respectively. The protecting group has good stability in acidic, basic, and thermal conditions and was successfully utilized for protection and deprotection of a variety of amines. A multistep continuous-flow synthesis of a piperazinylcarbonyl-piperidine derivative utilized the 2-methoxy-9-methylxanthene as the key protecting group utilized in an orthogonal manner.

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In this section of the journal, the literature on continuous-flow synthesis (primarily organic synthesis and functional materials) from the period of January–March 2015 is presented. All the publications are listed and ordered by journal name, with review articles grouped at the end. This time, there is no section on highlighted articles; however, from the next issue, a succinct overview of specific publications will be included in this section. From the next issue, some publications having engineering principles relevant to flow synthesis will also be included in this list with specific highlights that will give new insights on flow synthesis.

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