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treatment assignment can significantly influence both placebo and nocebo effects in psychedelic therapy. In a similar vein, Flameling, Aday, and Van Elk (2023) point out the potential for both placebo and nocebo effects in MDMA trials. It is described that

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Journal of Psychedelic Studies
Authors:
Cody Sykes Gilbert
,
Mitch Earleywine
,
Maha N. Mian
, and
Brianna R. Altman

., 2007 ). Researchers once praised MDMA, which increases activity in both systems, as a potential antidepressant ( Riedlinger & Riedlinger, 1994 ). MDMA-assisted treatment for other disorders appear to help depressive symptoms , though those in the

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, Wiegand, Taitano, & Delgado, 2006 ), end-of-life anxiety ( Griffiths et al., 2016 ), and substance use disorders ( Johnson, Garcia-Romeu, Cosimano, & Griffiths, 2014 ; Sessa et al., 2021 ). Most notably, the FDA designated MDMA-assisted psychotherapy a

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classes: classical psychedelics (e.g. Psilocybin, LSD, DMT), entactogens (e.g. MDMA), dissociative anaesthetics (e.g. Ketamine), and atypical hallucinogens (e.g. Ibogaine). Each of these different classes are characterised by unique pharmacological

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subscales. The MEQ-30 has demonstrated sensitivity in assessing the effects of a range of psychedelic compounds, including LSD ( Schmid & Liechti, 2018 ), MDMA ( Lyvers & Meester, 2012 ), psilocybin ( Barrett et al., 2015 ), ayahuasca ( Schenberg, Tofoli

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, DMT, and other substances, as seen in Table 1 . Table 1. Lifetime use of hallucinogens Hallucinogen Mean (SD) Median Range LSD 27.51 (104.99) 1.00 0–1,000 Mushrooms 25.64 (94.08) 5.00 0–1,000 MDMA 19.55 (82.7) 0.00 0–5 DMT 3.66 (11.21) 0.00 0

Open access
Journal of Psychedelic Studies
Authors:
Thaddeus James Camlin
,
Donald Eulert
,
Arthur Thomas Horvath
,
Steven F. Bucky
,
Joseph P. Barsuglia
, and
Martin Polanco

( Depoortere, 1987 ; Marrosu et al., 1995 ; Schneider & Sigg, 1957 ). If an ibogaine protocol is developed and psychotherapy is a part of it, as it is in the MDMA research protocol ( Mithoefer, 2017 ), then it may be worth considering the inclusion of

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, M. T. , Reed , S. , & Aggarwal , R. ( 2020 ). Culturally-informed research design issues in a study for MDMA-assisted psychotherapy for posttraumatic stress disorder . Journal of Psychedelic Studies , 4 ( 1 ), 40 – 50 . https://doi.org/10

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general public [Bachelor's thesis, University of Twente] . http://purl.utwente.nl/essays/82465 . Therapeutic Goods Administration ( 2023 , Feb 3). Change to classification of psilocybin and MDMA to enable prescribing by authorised psychiatrists

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Journal of Psychedelic Studies
Authors:
Sam Elias
,
Stephanie Spivak
,
Alexa Alverez
,
Alejandro Gili Olivares
,
Maria Ferrol
, and
Julian Paul Keenan

, K. H. , Heifets , B. D. , Hibicke , M. , Mitchell , J. , et al. ( 2021 ). Hallucinogens in mental health: Preclinical and clinical studies on LSD, psilocybin, MDMA, and ketamine . The Journal of Neuroscience: The Official Journal of the

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