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spectrometry (UPLC–QTOF-MS/MS), has become a very powerful tool for analyzing and identifying chemical compounds in complex samples due to its high resolution and high sensitivity [ 30 , 31 ]. In this paper, an efficient UPLC–QTOF-MS/MS method was

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detecting technique such as the chromatography tandem mass spectrometry (LC–MS/MS) method or ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOFMS). Beyond this, we utilize a rapid, precise, effective method of

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healing activities [ 9–14 ]. At present, the flavonoids of bamboo leaves have been marketed as health care products, suggesting their great development potential and research value. UPLC-ESI-Q-TOF-MS/MS has been recognized as a powerful tool for the

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manner. Both HPLC and UPLC utilize the basic concepts of liquid chromatography, however the former has been around since the 1960s, while the latter only surfaced in 2004, when Waters® developed their own UPLCTM devices. Both can be used for multiple LC

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liver metabolism in which lymphatic system uptake can possibly be executed. Lipid nanoarchitectonics are the most suitable approach for targeting lymphatic uptake and providing stability to incorporated drugs [ 7 , 8 ]. The UPLC-MS/MS validated method

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. There have been several literatures reported for determination f toddalolactone in Toddalia asiatica (L.) Lam. by HPLC or UPLC-QTOF-MS/MS [ 3–5 ]. However, until now, there have been no reports on the pharmacokinetic profile of toddalolactone in

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Retz extracts to rats using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC–QTOF-MS). This analysis method has the advantages of high sensitivity, good resolution, and high accuracy. The main active components

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), respectively. 0.9% saline and sodium heparin were purchased from Biosharp (China). UPLC-grade methanol, and acetonitrile were purchased from Merck (Germany). Sutent 50 was from Virbac (France). Sodium carboxymethyl cellulose (CMC-Na) was purchased from Macklin

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and rapid ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for the simultaneous determination of atractylenolide I, II, and III in rat plasma [ 1 ]. Plasma samples were processed by liquid–liquid extraction with

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, the object of current study was to establish a sensitive UPLC–MS/MS method for quantitation of eupatilin in rat plasma for the first time and apply it in the investigation of the pharmacokinetic properties of eupatilin. Experimental

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