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may lack specificity due to the presence of organic impurities. Notably, no single method for determining impurities in bulk drugs or Relugolix drug formulations using UPLC-PDA and MS has been reported until now. Furthermore, there is currently a
), Merck (Germany) and Watsons (China), respectively. Heparin sodium was from Biosharp (China). Zoletil™ 50 was from Virbac (France). Blank mouse plasma and brain samples were collected in our laboratory. Instruments and parameters for UPLC-MS/MS AB SCIEX
-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the quantification of erlotinib in rat plasma. Then the UPLC-MS/MS method was successfully applied to effect of Citrus suavissima Hort. ex Tanaka on pharmacokinetics of erlotinib in
spectrometry (UPLC–QTOF-MS/MS), has become a very powerful tool for analyzing and identifying chemical compounds in complex samples due to its high resolution and high sensitivity [ 30 , 31 ]. In this paper, an efficient UPLC–QTOF-MS/MS method was
detecting technique such as the chromatography tandem mass spectrometry (LC–MS/MS) method or ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOFMS). Beyond this, we utilize a rapid, precise, effective method of
healing activities [ 9–14 ]. At present, the flavonoids of bamboo leaves have been marketed as health care products, suggesting their great development potential and research value. UPLC-ESI-Q-TOF-MS/MS has been recognized as a powerful tool for the
manner. Both HPLC and UPLC utilize the basic concepts of liquid chromatography, however the former has been around since the 1960s, while the latter only surfaced in 2004, when Waters® developed their own UPLCTM devices. Both can be used for multiple LC
. There have been several literatures reported for determination f toddalolactone in Toddalia asiatica (L.) Lam. by HPLC or UPLC-QTOF-MS/MS [ 3–5 ]. However, until now, there have been no reports on the pharmacokinetic profile of toddalolactone in
liver metabolism in which lymphatic system uptake can possibly be executed. Lipid nanoarchitectonics are the most suitable approach for targeting lymphatic uptake and providing stability to incorporated drugs [ 7 , 8 ]. The UPLC-MS/MS validated method
Retz extracts to rats using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC–QTOF-MS). This analysis method has the advantages of high sensitivity, good resolution, and high accuracy. The main active components
