Authors:I. Czegle, É. Margittai, S. Senesi, A. Benedetti, and G. Bánhegyi
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADPH dependent oxidoreductase of the endoplasmic reticulum lumen which converts cortisone to cortisol and plays a role in the pathogenesis of metabolic syndrome and type 2 diabetes. The aim of our study was to investigate the correlation between the expression/activity of 11βHSD1 and obesity. Liver and adipose tissue microsomes of an obese (Zucker) and a non-obese (Goto-Kakizaki) type 2 diabetes model rat strains were used. 11βHSD1 expression was detected at mRNA, protein and activity level. The activity of 11βHSD1 was increased in the adipose tissue and decreased in the liver of the obese Zucker rat, while its mRNA levels were significantly different only in the adipose tissue. In diabetic Goto-Kakizaki rat both the expression and the activity of 11βHSD1 were elevated in liver, but not in adipose tissue. These results suggest that the prereceptorial glucocorticoid activation is different in the liver and adipose tissue of the two diabetes models. This phenomenon might be responsible for the obese and lean phenotypes in type 2 diabetes.
Authors:Boglárka Vincze, Márta Varga, Orsolya Kutasi, Petra Zenke, Ottó Szenci, Ferenc Baska, Alan Bartels, Sándor Spisák, Sándor Cseh, and Norbert Solymosi
Introduction Equine dysautonomia (also known as equine grass sickness, EGS) is a life-threatening disease of unknown aetiology, affecting horses. Approximately 80% of the affected animals die within days after the recognition of the first clinical
Knapen , F. , Nöckler , K. , Schenone , H. and Zhu , X. ( 2000 ): Recommendations on methods for the control of Trichinella in domestic and wild animals intended for human consumption . Vet. Parasitol. 93 , 393 – 408
Authors:Ákos Végh, Zsolt Abonyi-Tóth, and Pál Rafai
EFSA (European Food Safety Authority) ( 2004 ): Welfare aspects of the main systems of stunning and killing the main commercial species of animals . EFSA J. 45 , 1 – 29 .
EFSA AHAW Panel (EFSA Panel on Animal Health and
Authors:Neslihan Arıcı, Sebahat Aksaray, and Handan Ankaralı
total of 785 patient samples with suspicion of CSD were sent to our central laboratory in Istanbul. The demographic data, clinical characteristics and history of animal contact of the patients were collected from electronic medical records. Out of 78
Authors:Sae-Young Won, Yong-Chan Kim, and Byung-Hoon Jeong
Korean native black goats using Western blot analysis and analysed the haplotype distribution of the PRNP gene. Materials and methods Ethical statement All experimental procedures were reviewed and approved by the Institute of Animal Care and Use
, O’Leary DS , Parks CM , Poole DC , Ra’anan AW , Sheriff DD , Sturek MS , Toth LA : Resource book for the design of animal exercise protocols . American Physiology Society , Bethesda, USA ( 2006 )
3. Axelrod J , Reisine