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, the object of current study was to establish a sensitive UPLC–MS/MS method for quantitation of eupatilin in rat plasma for the first time and apply it in the investigation of the pharmacokinetic properties of eupatilin. Experimental

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–tandem mass spectrometry (LC–MS/MS), ultra-performance liquid chromatography–MS/MS (UPLC–MS/MS) is more sensitive, possessing significant advantages in the investigation on pharmacokinetics of drugs. Meanwhile, the powerful separation and analysis capacity are

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there is no literature about the determination of spiraeoside in biological samples by UPLC-MS/MS. In order to explore the therapeutic potential of spiraeoside in vivo, it is necessary to establish a rapid and simple bioanalytical method for its

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coupled with tandem mass spectrometry (UPLC-MS/MS) was a powerful tool for characterizing unknown compounds in complex natural medicines and clarifying the multiple compound, multiple target pharmacological mechanisms [ 8–10 ], but there were some

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behavior of shikonin, isobutyryl shikonin and β, βʹ -dimethylacryl alkanin in beagle dogs plasma. Ultra-high performance liquid chromatography (UPLC) is a commonly used chemical component separation technology, which has many advantages such as

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determination of the Aconitum alkaloids from YGY in plasma for investigating its pharmacological and toxicological effects, as well as monitoring therapeutic efficacy in clinic. In this study, we established a sensitive UPLC–ESI–MS method for simultaneous

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and rapid method based on ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) has been developed and validated for the determination of remimazolam and its major carboxylic acid metabolite (M1) in human urine [ 4 ]. The method

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were extraction time, temperature, and percentage of methanol in distilled water, with preliminary tests based on the one-variable-at-a-time approach. Notably, the active component DPT was detected by ultra-performance liquid chromatography (UPLC

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clinical value to study the intragastric pharmacokinetic characteristics of monomer. This work aims to develop a rapid ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for the determination of psoralidin in rat

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detection (UPLC–DAD) in leaves of a wild C. annuum [ 11 ]. However, HPLC method suffered from low resolution and sensitivity, long run time, and using a few analytes. In this study, phenolic compounds were analyzed by a sensitive and selective UPLC

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