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–tandem mass spectrometry (LC–MS/MS), ultra-performance liquid chromatography–MS/MS (UPLC–MS/MS) is more sensitive, possessing significant advantages in the investigation on pharmacokinetics of drugs. Meanwhile, the powerful separation and analysis capacity are

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there is no literature about the determination of spiraeoside in biological samples by UPLC-MS/MS. In order to explore the therapeutic potential of spiraeoside in vivo, it is necessary to establish a rapid and simple bioanalytical method for its

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coupled with tandem mass spectrometry (UPLC-MS/MS) was a powerful tool for characterizing unknown compounds in complex natural medicines and clarifying the multiple compound, multiple target pharmacological mechanisms [ 8–10 ], but there were some

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behavior of shikonin, isobutyryl shikonin and β, βʹ -dimethylacryl alkanin in beagle dogs plasma. Ultra-high performance liquid chromatography (UPLC) is a commonly used chemical component separation technology, which has many advantages such as

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determination of the Aconitum alkaloids from YGY in plasma for investigating its pharmacological and toxicological effects, as well as monitoring therapeutic efficacy in clinic. In this study, we established a sensitive UPLC–ESI–MS method for simultaneous

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and rapid method based on ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) has been developed and validated for the determination of remimazolam and its major carboxylic acid metabolite (M1) in human urine [ 4 ]. The method

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were extraction time, temperature, and percentage of methanol in distilled water, with preliminary tests based on the one-variable-at-a-time approach. Notably, the active component DPT was detected by ultra-performance liquid chromatography (UPLC

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clinical value to study the intragastric pharmacokinetic characteristics of monomer. This work aims to develop a rapid ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for the determination of psoralidin in rat

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detection (UPLC–DAD) in leaves of a wild C. annuum [ 11 ]. However, HPLC method suffered from low resolution and sensitivity, long run time, and using a few analytes. In this study, phenolic compounds were analyzed by a sensitive and selective UPLC

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Summary

The objective of the work was continuation of our study on identification of target coumarins in extracts from Peucedanum alsaticum L. and Peucedanum cervaria (L.) Lap., by use of ChromSword, on the basis of relationships between retention data and descriptors such as partial molecular volume of structural fragments in water and energies of electrostatic interactions of bond dipoles with water (QSRR). The coumarins were mainly identified by comparing UV spectra from gradient runs with spectra from the literature. The presence of columbianadin, ostruthin, and 8-methoxypeucedanin in the fruits of P. cervaria (L.) Lap. and oxypeucedanin and isoimperatorin in the fruits of P. alsaticum was confirmed. The optimum conditions obtained from DryLab simulation were used for both RP-HPLC and RP-UPLC.

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