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( 2005 ) 1 – 14 . [6] D.A. Sica , T.W. Gehr , S. Ghosh , Clinical pharmacokinetics of losartan , Clin. Pharmacokinet. 44 ( 2005 ) 797 – 814

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Acta Chromatographica
Authors: Weijian Ye, Wei Sun, Ruijie Chen, Zhe Wang, Xiao Cui, Hui Zhang, Shuyi Qian, Qi Zheng, Yangfeng Zhou, Jiafeng Wan, Jiali Xu, Xianqin Wang, and Yunfang Zhou

–liquid extraction for sample preparation, and the method was applied to study pharmacokinetics after oral (p.o.) administration [ 13 ]. Careri et al. established an LC–MS method for the analysis of several flavonoids including GAL [ 14 ]. Chen et al . developed an

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complexes. To better understand the pharmacokinetics [ 14 , 15 ], an analytical method for the determination of narciclasine in biological fluids is necessary. Svagrova et al. developed a reversed-phase high-performance liquid chromatography for

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Acta Chromatographica
Authors: Ruijie Chen, Mengrou Lu, Xiaoting Tu, Wei Sun, Weijian Ye, Jianshe Ma, Congcong Wen, Xianqin Wang, and Peiwu Geng

faster, offering significant advantages in the investigation of pharmacokinetics of chemical drugs [ 6 , 7 ]. In our study, we developed a sensitive UPLC–MS/MS method for quantification of panasenoside in rat plasma and mouse tissues (heart, liver

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Acta Chromatographica
Authors: Xiaoyan Zhang, Jie Liu, Wenbo Sun, Xiangchun Shen, Xiaojian Gong, Cong Wang, Yan Liang, and Wei Zhou

same therapeutical effect. Chemical fingerprint–pharmacokinetics–pharmacodynamics (CF–PK–PD) analytical method was first proposed by our research group in 2013 [ 13 ], this research strategy was applied to closely link CF, PK and PD, combine time

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Acta Chromatographica
Authors: Jinzhao Yang, Huamin Liu, Yuan Cai, Yazhen Wu, Xiaoxin Xu, Xianqin Wang, and Chongliang Lin

suavissima Hort. ex Tanaka juice on the pharmacokinetics and adverse reactions of erlotinib are of great significance for rational and safe drug use. Fig. 1. Molecular structure of erlotinib Consequently, in the present study, we established an ultra

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endoxylanase and Aspergillus niger glucoamylase [ 1 ]. Pharmacokinetic, was a science that uses mathematical analysis to deal with the dynamic processes of drugs in the body [ 4–8 ]. Until now, there were no reports about the pharmacokinetics of eugenitin

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. There have been several literatures reported for determination f toddalolactone in Toddalia asiatica (L.) Lam. by HPLC or UPLC-QTOF-MS/MS [ 3–5 ]. However, until now, there have been no reports on the pharmacokinetic profile of toddalolactone in

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–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for simultaneous determination of PA-824, moxifloxacin, and pyrazinamide in rat plasma and its application to a pharmacokinetic study in rats. To further clarify the DDI between the

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. There is a need to develop inexpensive method for the combined determination of PSS and DM in plasma for the calculation of pharmacokinetic parameters. High-performance liquid chromatography with UV detection (HPLC–UV) exploits an extensive

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