Authors:K. Dagdeviren, P. Ünak, R. Bekis, F. Biber, S. Akdurak, O. Ulker, B. Ergur, T. Ertay, and H. Durak
Magnetically targeted drug delivery by particulate carriers is an efficient method of delivering drugs to localized disease
sites, such as tumors. Thus, high concentrations of carrier molecules such as therapeutic radiopharmaceuticals can be achieved
near the target site without any toxic effects to normal surrounding tissue. In this study, magnetic targeting carriers (MTC)
were radioiodinated with 131I using three different methods (1) 131I was directly bound onto MTC, (2) an iron complex of 8-hydroxyquinoline (8-OHQ) has been absorbed onto magnetic microspheres.
The iodogen method was performed for the iodination of the complexes. (3) 8-OHQ was radioiodinated before chelating with Fe.
Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The best labeling yield
and the best stability were obtained when 8-OHQ was chelated before the radioiodination. Binding efficiency was found to be
99.58%. The labeling of the MTC with 131I was undertaken to allow for therapy with 131I-labeled MTC with simultaneous imaging.
A simple preconcentration method is described for the simultaneous coprecipitation of Cd(II), Co(II), Cu(II), Mo(VI), U(VI), V(V) and Zn(II) from surface water samples followed by quantitation using neutron activation analysis. Ammonium pyrrolidinedithiocarbanate (APDC), anthranilic acid and 8-hydroxyquinoline have been investigated as possible coprecipitating agents. The suitability of Bi3+, Fe3+, Ni2+ and Pb2+ ions as metal carriers has also been studied. It has been found that the above elements can be quantitatively coprecipitated with APDC in the presence of Bi3+ carrier at pH 4. The precision and accuracy of the method for all elements are found to be between ±2 and 10%. The enrichment factors are of the order of 103. The detection limits are in the ppb range varying between 0.04 ng · ml–1 for Co and V and 5 ng · ml–1 for Zn. The method has been applied to tap and well waters, and river and lake water samples collected from Halifax County, Nova Scotia.
Prior work had documented that99mTcCl
could undergo ready ligand exchange reaction under non-aqueous condition. We now wish to report the ligand exchange reaction of bromine in99mTcBr
in non-aqueous solvents using 8-hydroxyquinoline (oxine) as the displacing ligand. Analysis of the products obtained by paper chromatography, HPLC and electrophoresis suggest that a 12 Tcoxine complex appears to be the most stable of the complexes formed, probably99mTc(oxine)2 Br2. However, displacement of bromine by polar solvents (both protic and aprotic) can also occur, both on99mTcBr
and in the above complex as a consequence of solvolytic reactions. Other Tc-oxine complexes can also be formed upon ligand exchange, but they appear to be stable only under aprotic, non solvolytic conditions. These studies again document that hexahalotechnetate complexes exhibit ligand exchange reactions under non-aqueous conditions, that they allow the ready synthesis of novel technetium complexes, but that because of their high reactivity the effect of competing reactions must be considered.
Authors:E. A. A. El-Shazly, R. R. Sheha, and H. H. Someda
in benzene, xylene, chloroform and toluene diluents was used to modify silica
gel as a solid phase extractant (SPE) for the sorption of Eu(III) in batch
extraction techniques. Influences of solid/liquid ratio, pH, metal ion
concentration, particle size and temperature were studied. The optimum initial
pH is 4.2, while the maximum sorption capacities for the prepared impregnated
resins in benzene, xylene, chloroform and toluene diluents are 18.52, 14.98,
14.79 and 5.94 mg . g-1, respectively. The sorption
process is found to be affected by both metal ion concentration and particle
size of the impregnated resin. Thermodynamic parameters for the sorption of
Eu(III) were determined and the reaction is found to be exothermic and spontaneous
kJ . mol-1 for benzene and xylene as diluents. Release of
the element from the loaded solid particles into 0.01M HNO3 is@85% and@53% from
8-HQ/benzene/silica gel and 8-HQ/xylene/silica gel.
Cut flowers of Dianthus caryophyllus L. cv. Asso were treated with 8-hydroxyquinoline sulphate (8-HQS) at 200 and 400 ppm with or without sucrose at 50 g l-1, silver thiosulphate (STS) at 0.2 and 0.4 mM with or without sucrose at 50 g l-1,and 1-methylcyclopropene (1-MCP) at 0.3, 0.5 and 0.7 g m-3 for 6 h to study the effect of these chemicals on post-harvest quality. 8-HQS treatments increased the vase life and the percentage loss of initial fresh weight compared to the control. In addition, the vase life was longer when sucrose was applied in combination with 8-HQS. The best treatment involved 400 ppm 8-HQS + 50 g l-1 sucrose. All the concentrations of STS prolonged the vase life and fresh mass compared to the control. The best treatment was STS at 0.4 mM with or without sucrose. All levels of 1-MCP prolonged the vase life and increased the fresh weight in comparison with the control. The best treatment in this respect was 1-MCP at 0.5 g m-3 for 6 h. The chlorophyll content (chl a and chl b) in the leaves was higher than the control in the best treatment of each chemical.
Authors:S. Z. Haider, K. M. A. Malik, A. Rahman, and T. Wadsten
Six adducts of the tctrakis(8-hydroxyquinolinato) complex of thorium(IV) with 8-hydroxyquinoline, pyridine, urea, dimethylsulphoxide, dimethylformamide and 1,10-phenanthroline were prepared and characterized, the infrared bands for the room-temperature forms are given and their particular thermal properties are reported. The thermal analyses were performed mostly in the presence of air, but in some cases an argon atmosphere was used for comparison. The adducts were lost from the principal complex at temperatures varying between 110 and 290°. Intermediate oxygenated complexes were formed in each case at about 400°. The thermal data suggest the standardization of a procedure for the formation of Th(C9H6NO)4.
importance. Likewise, 8-hydroxyquinoline and its derivatives constitute another group of biologically important ligands exhibiting predominantly antimicrobial activities [ 6 – 9 ]. These two groups of ligands have been of an enormous research interest in the
Authors:M. Gaber, G. B. El-Hefnawy, M. A. El-Borai, and N. F. Mohamed
8-hydroxyquinoline derivatives play a central role as chelating agents for a large number of metal ions [ 21 – 24 ]. Also, some 8-hydroxyquinoline and azo derivatives found numerous applications in analytical chemistry as chromophoric and