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). MDMA-Assisted therapy for severe PTSD: A randomized, double-blind, placebo-controlled phase 3 study . Nature Medicine , 27 ( 6 ), 1025 – 1033 . https://doi.org/10.1038/s41591-021-01336-3 . Mithoefer , M. C. , Mithoefer , A. T. , Feduccia , A. A

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hallucinogens: eight participants. – Psilocybin: (“magic mushrooms”) ranging from one trial to monthly use, and from 1-year use up to 10 years; – LSD: ranging from one trial to monthly use, and from 1-year use up to 10 years; – MDMA (Ecstasy): ranging from one

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recently defined by the journal Psychedelic Medicine as serotonergic agonists that expand brain network connectivity by activating 5-HT2A receptors. They include classic psychedelics (psilocybin, mescaline, DMT, and LSD) as well as ketamine and MDMA

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is a member of a closed ayahuasca Facebook group, approximately between 22 and 67 years old and holds a rather high education degree and might be preexperienced in psychedelics such as psilocybin (“magic mushrooms”), MDMA (“ecstasy”), cannabis, and

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, A. , Jerome , L. , Mithoefer , A. , Wagner , M. , Walsh , Z. , Hamilton , S. , Yazar-Klosinski , B. , Emerson , A. & Doblin , R. ( 2019 ). MDMA-Assisted psychotherapy for treatment of PTSD: Study design and rationale for phase 3

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“relive the drug taking experience in their imagination” ( Baumann, 1970 , p. 20) with similar findings indicated more recently in a group of 3,4-Methylenedioxymethamphetamine (MDMA) users ( Hastings, 2006 ) suggesting the re-accessing of psychedelic

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) reported on the efficacy of MDMA and psilocybin in treating symptoms of PTSD and depression, but noted that confounders, patient bias, and challenges associated with blinding remain. Recent articles provide a valuable analysis of methodological problems

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-drug interactions between psychiatric medications and MDMA or psilocybin: A systematic review . Psychopharmacology , 239 , 1945 – 1976 . https://doi.org/10.1007/s00213-022-06083-y . 10.1007/s00213-022-06083-y

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-site crossover study to assess psychological effects of MDMA when administered to healthy volunteers . Retrieved 28 June 2020 from https://mapscontent.s3-us-west-1.amazonaws.com/pdfs/MT1+Santized+for+Website+Protocol+A5V2+Clean+08APR2020.pdf . Muthukumaraswamy

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, E. , & Marcela Ot’alora , G. ( 2013 ). A manual for MDMA-assisted psychotherapy in the treatment of posttraumatic stress disorder . Priest , G. , Tanaka , K. , & Weber , Z. ( 1996 ). Paraconsistent logic . Roseman , L. , Nutt , D. J

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