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Az idősödés során jellemző genetikai és epigenetikai változások és a gammopátiák progressziója •
A myeloma multiplex az öregedés egyik arca lehet?
Age-related genetic and epigenetic changes and the progression of gammopathies?
, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment . Geroscience 2022 : 1–20 . Epub 2022/12/13 . https://doi.org/10.1007/s11357-022-00698-x . PubMed PMID: 36508077; PubMed Central PMCID: PMCPMC
Abstract
A non-homogeneous birth process is used to describe the statistical properties of bibliometric citation processes. The model is analysed under special assumptions. Thelife-time distribution, special probabilities and mean value functions are used to characterize differences in the ageing structure of scientific literature, the change of citation impact in time and to analyse predictive aspects of reception processes. The results are applied to selected journals representing one field in science and social science each. The empirical part of the study is based on a 14-year citation history (papers published in 1978 and cited 1978–1991). An intimate, connection between impact and ageing cannot be observed. However, the ageing behaviour seems to be clearly influenced by field characteristics and by special document/journal types, such as letters and short communications.
Abstract
Glass transition temperature of red crayfish flour (moisture 3.56%) was determined using a phase transition analyser (Wenger Technical Centre, USA). Due to the importance of physical ageing in functional properties of red crayfish flour (with 65% protein) the possible occurrence of physical ageing in dry powder of crayfish flour was studied at different temperatures below and close to the glass transition. Endothermic peaks that corresponded to relaxation enthalpy were observed for a commercial crayfish flour with 4.5% moisture. Enthalpy and peak temperature increased on storage of crayfish flour when it was held in the glassy-state at different temperatures (5, 15, 25°C).
Vyas, K., Eklem, M., Seto, H. és mtsai: Quantitative scintigraphy of sacroiliac joints: Effect of age, gender and laterality. AJR, 1981, 136 , 589–592. Seto H. Quantitative
-related brain potentials: Effects of normal aging on the scalp distribution of N1, P2, N2 and P300 latencies and amplitudes . Electroencephalography and Clinical Neurophysiology , 99 , 458 – 472 . 3
A DNS epigenetikai változásai és vizsgálati módszerei
Epigenetic changes of DNA and their research methods
ageing. Nat Rev Genet. 2018; 19: 371–384. 43 Cui J, Shen Y, Li R. Estrogen synthesis and signaling pathways during aging: from periphery to brain
The global population is ageing. Elderly people suffer from more severe infections than younger persons. The major reason for the increased susceptibility to infections in the elderly is the deregulated functions of the immune system. Immunosenescence affects both innate and adaptive immune reactions. Among these, quantitative alterations of B lymphocyte subsets determine outcome of infections and vaccination. The overall number of B cells seems to be stable or the decrease is moderate. Reduced input of naive B lymphocytes is compensated by anergic, exhausted memory cells. Concerning B lymphocyte subsets, experimental data obtained in the mouse model and in vivo studies conducted in old-age humans are frequently controversial. Further analysis of human B lymphocyte subpopulations is required that could be regarded as an important biomarker of human life span.
Zarbin, M. A.: Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol., 2004, 122 , 598–614. Zarbin M. A
. 2. Bugg , J. M. , Zook , N. A. , DeLosh , E. L. , Davalos , D. B. , Davis , H. P. ( 2006 ): Age differences in fluid intelligence: contributions of general slowing and frontal decline . Brain Cogn , 62 , 9
young and aged rats. Mech. Ageing Dev. 122, 1707–1721. Yasuhara M. Dopamine and serotonin uptake inhibitors on the release of dopamine and serotonin in the nucleus accumbens of young
