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Abstract

Flow diverters (FDs) have been successfully applied in the recent decade to the treatment of intracranial aneurysms by impairing the communication between the flows in the parent artery and the aneurysm and, thus, the blood within the aneurysm sac. It would be desirable to have a simple and accurate computational method to follow the changes in the peri- and intraaneurysmal flow caused by the presence of FDs. The detailed flow simulation around the intricate wire structure of the FDs has three disadvantages: need for high amount of computational resources and highly skilled professionals to prepare the computational grid, and also the lack of validation that makes the invested effort questionable. In this paper, we propose a porous layer method to model the hydraulic resistance (HR) of one or several layers of the FDs. The basis of this proposal is twofold: first, from an application point of view, the only interesting parameter regarding the function of the FD is its HR; second, we have developed a method to measure the HR with a simple apparatus. We present the results of these measurements and demonstrate their utility in numerical simulations of patient-specific aneurysm simulations.

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Arterial thrombosis is extremely rare in patients with factor V Leiden (FVL) mutation. Recent advances in multislice computed tomography (MSCT) technology facilitated diagnosis of thromboembolic events accurately without delay. We report a patient with FVL mutation and acute bilateral lower extremity deep venous thromboses, pulmonary thromboembolism, and acute left anterior descending artery thrombosis, all diagnosed by MSCT. MSCT has been utilized for prompt diagnosis of the concomitant thrombotic pathologies simultaneously.

Open access

A digitális technológia kínálta új lehetőségek a melanoma malignum szűrésében.

Szakirodalmi áttekintés

New opportunities offered by digital technology in melanoma malignum screening.

A literature review
Orvosi Hetilap
Authors:
Szabolcs Farkas-Ráduly
,
Marcell Csanádi
,
Tamás Ágh
,
Orsolya Szász
,
Zoltán Vokó
, and
György Széles

surveillance of cutaneous malignancies. Am J Med. 2020; 133: 417–423. 46 Young AT, Vora NB, Cortez J, et al. The role of technology in melanoma screening and

Open access

A gerincvelői izomsorvadás újszülöttkori szűrésének eredményei Magyarországon 2023-ban

Results of neonatal screening for spinal muscular atrophy in Hungary in 2023

Orvosi Hetilap
Authors:
Borbála Mikos
,
Mária Judit Molnár
,
Ildikó Szatmári
,
Péter Monostori
,
Csaba Bereczki
,
Attila József Szabó
,
Léna Szabó
,
Katalin Csősz
,
Béla Muzsik
, and
György János Velkey

technology evaluation 15. Pharmacoecon Open 2023; 7: 863–875. Erratum: Pharmacoecon Open 2023; 7: 1015. 5 Crawford TO, Swoboda KJ, DeVivo DC, et al

Open access

Despite concerted efforts, diagnosis of aspergillosis is still a great challenge to clinical microbiology laboratories. Along with the requirement for high sensitivity and specificity, species-specific identification is important. We developed rapid, sensitive and species-specific qPCR assays using the TaqMan technology for the detection and identification of Aspergillus fumigatus and Aspergillus terreus. The assays were designed to target orthologs of the Streptomyces factor C gene that are only found in a few species of filamentous fungi. Fungi acquired this gene through horizontal gene transfer and divergence of the gene allows identification of species. The assays have potential as a molecular diagnosis tool for the early detection of fungal infection caused by Aspergillus fumigatus and Aspergillus terreus, which merits future diagnostic studies. The assays were sensitive enough to detect a few genomic equivalents in blood samples.

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Interventional Medicine and Applied Science
Authors:
Dániel Lex
,
Péter Szántó
,
Tamás Breuer
,
Roland Tóth
,
Mihály Gergely
,
Zsolt Prodán
,
Erzsébet Sápi
,
András Szatmári
,
Tamás Szántó
,
János Gál
, and
Andrea Székely

Open access

Abstract

The basidiomycetes yeast Trichosporon is widespread in the natural environment, but can cause disease, mainly in immunocompromised patients. However, there have been only few studies about this infection in Thailand. In this study, we characterized 53 Trichosporon spp. isolated from urine samples from patients admitted to a single hospital in Bangkok, Thailand over a one-year period from 2019 to 2020. The strains were identified using colony morphology, microscopy, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and nucleotide sequence analysis of intergenic spacer 1 (IGS1). Fifty-one isolates were Trichosporon asahii, and the remaining isolates were Trichosporon inkin and other Trichosporon species. Three genotypes of IGS1—1, 3, and 7 were observed among T. asahii. The sensitivity of the yeasts to the antifungal drugs amphotericin B, fluconazole, and voriconazole ranged from 0.25 to >16 μg ml−1, 0.5–8 μg ml−1, and 0.01–0.25 μg ml−1, respectively. We investigated biofilm formation by the isolates, and no biofilm production was found in one isolate, low biofilm production in forty-four isolates, and medium biofilm production in six isolates. T. inkin produced biofilms at low levels, and Trichosporon spp. produced biofilms at medium levels. This research increases our understanding of the molecular epidemiology of Trichosporon spp. isolated from one university hospital in Bangkok, Thailand, and reveals their genetic diversity, antifungal susceptibility profiles, and capacity for in vitro biofilm production.

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Egészséggel kapcsolatos célok Crohn-betegek körében.

Az infokommunikációs eszközök szerepe

Health goals amongst patients with Crohn’s disease.

The role of the internet and digital technology
Orvosi Hetilap
Authors:
Blanka Festő
,
Sanela Njers
,
Anett Dávid
,
Barbara Horvát
,
Viola Sallay
,
Tamás Molnár
,
Beatrix Rafael
, and
Tamás Martos

Burke M, Settles B. Plugged in to the community: social motivators in online goal-setting groups. In: Proceedings of the Fifth International Conference on Communities and Technologies, C&T 2011, Brisbane, QLD, June

Open access

Personal choice is a nuanced concept – Lessons learned from the gambling field

Commentary on: Problematic risk-taking involving emerging technologies: A Stakeholder framework to minimize harms (Swanton et al., 2019)

Journal of Behavioral Addictions
Author:
David C. Hodgins

Swanton, Blaszczynski, Forlini, Starcevic, and Gainsbury (2019) propose a thoughtful framework for minimizing the personal harm that is potentially associated with new technologies. Broadly defined these technologies and behaviors include online

Open access

Gyermekkori genetikai rendellenességek diagnosztikája újgenerációs szekvenálással

Diagnosis of genetic disorders in childhood with next-generation sequencing

Orvosi Hetilap
Authors:
Otília Menyhárt
,
Balázs Győrffy
, and
András Szabó

Az újgenerációs szekvenáláson (NGS) alapuló diagnosztika legnagyobb előnye, hogy nagyszámú gén párhuzamos szekvenálása révén a genetikai rendellenességek kiterjedt repertoárját képes egyetlen vizsgálattal lefedni. Az analízis viszonylag kisebb költsége és az adatmennyiség kezelhetőbb mennyisége folytán a célzott génpanelek használata, illetve a teljesexom-szekvenálás (WES) a leginkább elérhető NGS-alapú módszer. Összefoglalónkban az NGS létjogosultságát vizsgáljuk gyermekkori genetikai rendellenességek diagnosztikájában. Áttekintjük az öröklött anyagcserezavarok, daganatos megbetegedések és egyéb gyermekkori genetikai rendellenességek NGS-alapú diagnosztikájában fontos szerepet játszó géneket. A kora gyermekkori rendellenességek NGS-alapú diagnosztikájának rutinszerű használata előtt számos technikai és klinikai kérdés vár még megválaszolásra. Jelenleg a legnagyobb kihívást a ritka genetikai variánsok értelmezése és a mutációk patogenitásának igazolása jelenti. Orv Hetil. 2022; 163(51): 2027–2040.

Open access