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Jobb oldali videoasszisztált thoracoscopos thymectomia a thymoma nélküli, felnőttkori myasthenia gravis sebészi kezelésében

Application of video-assisted thoracoscopy in the surgical treatment of myasthenia gravis in adults without thymoma

Magyar Sebészet
Authors: József Kas, Levente Bogyó, Attila Farkas, Csaba Fehér, Áron Ghimessy, Balázs Gieszer, Luca Karskó, Lóránt Kecskés, Viktor Lungu, László Mészáros, Miklós Molnár, Petra Németh, Ágoston Pataki, Péter Radeczky, Róbert Szegedi, Bernadett Tallósy, Klára Török, Attila Vágvölgyi, Csilla Rózsa, Katalin Török, Sámuel Komoly, Jenő Elek, János Fillinger, László Agócs, Ferenc Rényi-Vámos, and Ákos Kocsis

standards. Neurology 2000; 55: 16–23. 15 Furák J, Troján I, Szőke T, Lázár G: Videothoracoscopos, kiterjesztett thymectomia a myasthenia gravis kezelésében

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disorders (e.g., Su et al., 2017 ; Zhao, Liu, & Maes, 2017 ). In this task, respondents are requested to react to a frequent standard stimulus and infrequent deviant stimuli. For this reason, deviant stimuli comprise the detection of response conflict

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Orvosi Hetilap
Authors: Gergely György Nagy, Zsuzsa Tudlik, Lajos Gergely, József Kónya, Piroska Orosi, Éva Rákóczi, Judit Szabó, Csaba Várvölgyi, Eszter Vitális, and György Paragh

] 41 Udvardy M. A new era of transfusion-transmitted pathogens, infections. Renewed need for updating standards for clinicans along with blood banking. [Új korszak és új szempontok a transzfúzios

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Absztrakt:

A krónikus lymphocytás leukaemia (CLL) heterogén klinikai lefolyású lymphoproliferativ betegség, amelyben számos klinikai és molekuláris prognosztikai marker nyújt segítséget a leghatékonyabb terápia megválasztásában. Eddig a TP53-defektus bizonyult kulcsfontosságú prognosztikai és prediktív faktornak, amely befolyásolja a terápiás döntést, különösen az új célzott kezelések érájában. A tünetmentes, korai stádiumú betegek nem igényelnek kezelést, követésük javasolt (úgynevezett „watch and wait”). Első vonalban a standard rizikójú CLL-es betegek többségében a standard kezelés továbbra is a kemo-immuno terápia. Az új orálisan alkalmazható kis molekulájú gyógyszereknek, mint a kinázinhibitorok (KI) és a Bcl-2-gátlók (ibrutinib, idelalisib és venetoclax), elsősorban relabáló/refrakter CLL kezelésében van helyük, ez alól kivétel az ibrutinib-monoterápia, amely a nagy rizikójú (TP53-defektust hordozó) betegek első vonalbeli kezelésére is javasolt. A nem túl távoli jövőben az új generációs szekvenálás diagnosztikába történő integrálása támogathatja majd a CLL-es betegek személyre szabott ellátását és az optimális kezelési stratégia megválasztását. Orv Hetil. 2017; 158(41): 1620–1629.

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. ( 2012 ): Bordetella avium antibiotic resistance, novel enrichment culture, and antigenic characterization . Vet. Microbiol . 160 , 189 – 3 . Clinical and Laboratory Standards Institute (formerly: National

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Acta Veterinaria Hungarica
Authors: Orsolya Erdősi, Katalin Szakmár, Zsuzsanna Szili, Géza Szita, Sándor Bernáth, József Sövényi, and Péter Laczay

The rapid detection of Campylobacter spp. is of utmost importance for the reduction of infections in humans by contaminated food products. The standard culturing method (ISO 10272-1:2006) involves a high time and labour demand. In this paper, we present a method that reduces the detection time of Campylobacter spp. to or below one third as compared to the ISO method, at a reduced cost per test. We used redox potential change of enrichment cultures (Bolton broth with Bolton selective supplement) for reliably selecting Campylobacter-contaminated raw milk and broiler meat samples. Identification of Campylobacter spp. in the contaminated samples was done by real-time PCR method. Culturing time to conclusive redox monitoring varied between 6 and 24 h for positive samples, depending on the contamination rate, in contrast to 136 h with the standard culturing process. However, now the Campylobacter-negative majority of food samples will not need to be tested by real-time PCR because redox potential monitoring can identify them in the selective enrichment phase. This method could be potentially used as a faster alternative to the current standard ISO 10272-1:2006, for nonregulatory monitoring purposes.

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Introduction: In the past decade several multicentre, prospective, randomised trials have revealed a significant progress in the therapy for chronic viral hepatitis, but only limited and contradictory data are available regarding the real value of the antiviral treatment in the everyday routine clinical practice. Objective: A nation-wide retrospective analysis has been performed in order to assess the efficacy of antiviral therapy for patients with chronic hepatitis B and C representing the entire population that needed treatment in Hungary during a seven-year period. In addition, results of a prospective Hungarian study including patients with chronic hepatitis C are also presented. Patients and methods: A total of 220 patients with chronic hepatitis B treated with standard interferon-alpha (112), pegylated interferon-alpha-2a (23) or lamivudine (85) were investigated and the ratio of HBeAg seroconversion and/or undetectable HBV-DNA has been assessed. Of the 2442 patients with chronic hepatitis C, 333 were treated with standard interferon monotherapy, 1122 with standard interferon + ribavirin and 987 with pegylated interferon + ribavirin combination for 6 to 12 months. In a prospective study, 69 patients with chronic hepatitis C were enrolled and treated with pegylated interferon-alpha-2a + ribavirin. The rate of sustained virological response, the predictors of outcome and the adverse effects of treatment were evaluated. Results: For HBV patients standard IFN, PEG-IFN and lamivudine provided 31, 30, and 31 to 33% sustained virological response rate, respectively. In chronic hepatitis C, a continuous improvement was noted in sustained virological response, from 13% with interferon monotherapy to 31% with pegylated interferon + ribavirin combination, while even a 48% sustained virological response has been achieved in the prospective trial. The most important predictors of outcome were the 4-week ‘rapid’ and 12-week ‘early’ virological responses, then female gender, age, BMI and adherence. The most frequent complications of the treatment were cytopenia, haemolysis and depression, occurring in 9% of patients. Conclusion: Unlike in HBV infection, in chronic HCV hepatitis the efficacy of antiviral treatment has gradually improved in our everyday clinical practice, but the results are far poorer than those achieved in a prospective study. To manage the growing populations of hard-to-treat patients with chronic viral hepatitis, there is a need for more effective treatment modalities, including optimalized, individualized dosing and novel antiviral agents.

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Magyar Onkológia
Authors: Miklós Kásler, Éva Remenár, András Boér, Emőke Iványi, and Miklós Fülöp

Absztrakt

A szájüregi daganatos esetek nagyobb részében előrehaladott daganatok kezelését kell megoldani. Ezekben az esetekben rákényszerülhetünk a mandibula egy részének eltávolítására. Csonthiányok rekonstrukciójára a fibula-szabadlebenyt használjuk, cikkünkben 25 éves tapasztalatainkat részletezzük.

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Orvosi Hetilap
Authors: Gergely Fügedi, Judit Lám, and Éva Belicza

Healthcare Accreditation. Int. J. Qual. Health Care, 1999, 11 (4), 275–277. 13 ISQua Accredited Organisations and Standards. International Society for Quality in Health Care

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Acta Physiologica Hungarica
Authors: R Bravo Santos, J Delgado, J Cubero, L Franco, S Ruiz-Moyano, M Mesa, AB Rodríguez, C Uguz, and C Barriga

The objective of the present study was to compare differences between elderly rats and young obesity-induced rats in their activity/inactivity circadian rhythm. The investigation was motivated by the differences reported previously for the circadian rhythms of both obese and elderly humans (and other animals), and those of healthy, young or mature individuals. Three groups of rats were formed: a young control group which was fed a standard chow for rodents; a young obesity-induced group which was fed a high-fat diet for four months; and an elderly control group with rats aged 2.5 years that was fed a standard chow for rodents. Activity/inactivity data were registered through actimetry using infrared actimeter systems in each cage to detect activity. Data were logged on a computer and chronobiological analysis were performed. The results showed diurnal activity (sleep time), nocturnal activity (awake time), amplitude, acrophase, and interdaily stability to be similar between the young obesity-induced group and the elderly control group, but different in the young control group. We have concluded that obesity leads to a chronodisruption status in the body similar to the circadian rhythm degradation observed in the elderly.

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