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experiment conducted with an animal model, it was shown that HMOX1 stimulated insulin products and reduced IR. It was also reported that biliverdin reductase has multiple functions affecting cell signaling and modulating immune system response [ 16

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Fulchuk KH, Contin JM, Dzedzic TS, Feng Z, French TC, Heffron GJ, et al.: A role for biliverdin IXa in dorsal axis development of Xenopus laevis embryos. Proc. Natl. Acad. Sci. USA. 99, 251–256 (2002) Heffron G

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to iron and porphyrin IXa and porphyrin IX to biliverdin by hem oxygenase. The green coloured biliverdin is then reduced to yellow coloured bilirubin by biliverdin reductase [ 3–5 ] ( Fig. 1 ). The bilirubin molecule thus formed consists of a

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Stocker, R., Peterhans, E.: Antioxidant properties of conjugated bilirubin and biliverdin biologically relevant scavenging of hypochlorous acid. Free Rad. Res. Com., 1989, 6 , 57–66. Peterhans E

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a ubiquitous microsomal rate-limiting enzyme involved in the oxidative degradation of heme to biliverdin (BV), which is rapidly converted into bilirubin (BR) by BV reductase. During this step, iron is released from the heme ring and carbon monoxide

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