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Semsei I.: On the nature of aging. Mech. Ageing Dev., 2000, 117 , 93–108. Semsei I. On the nature of aging
Grimley, E. J., Bond, J.: The challenges of age research. Age Ageing, 1997, 26 (Suppl) , 43–46. Bond J. The challenges of
abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet., 2006, 38 (5), 518–520. Mattson, M. P., Magnus, T.: Ageing and neuronal vulnerability. Nat. Rev. Neurosci., 2006, 7 (4
PMCID: PMCPMC3679661 . 10.1523/JNEUROSCI.5457-12.2013 54. Keating C , Nocchi L , Yu Y , Donovan J , Grundy D . Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse . The
To investigate the relationships between site-specific muscle loss in the thigh, muscle quality and zigzag walking performance, 40 men and 41 women aged 65–79 years had muscle thickness (MTH) measured by ultrasound at nine sites on the anterior and posterior aspects of the body. Skeletal muscle mass (SM) was estimated from an ultrasoundderived prediction equation. Site-specific thigh sarcopenia was calculated using ultrasound-measured MTH at the anterior/posterior aspects of the thigh (AP-MTH ratio). Zigzag walking time (ZWT) and maximum isometric knee extension (KE) and flexion (KF) torques were measured. Muscle quality (torque/thigh SM) and knee joint strength index (torque/body mass) were calculated. There were no significant correlations between SM index and ZWT. However, AP-MTH ratio was inversely correlated (P < 0.05) to ZWT in men (r = −0.335) and women (r = −0.309). ZWT was also inversely correlated (P < 0.05) to KE-strength index in both sexes (men, r = −0.328; women, r = −0.372). Similarly, ZWT was correlated to KF-strength index (r = −0.497) and muscle quality (r = −0.322) in women, but not in men. After adjusting for age, height and body mass, AP-MTH ratio was inversely correlated to ZWT in men (r = −0.325) and tended to be correlated to ZWT in women (r = −0.263). Zigzag walking performance may be associated with site-specific thigh sarcopenia in older men and women.
Introduction The aging of the skin not only causes structural and subsequent physiological changes to the skin but also leads to the development of benign and malignant tumours in elderly people. The most
proliferation and decreased apoptosis in the colonic mucosa. Mech. Ageing Dev., 2001, 122 , 1849–1864. Jaszewski R. Aging is associated with increased proliferation and decreased
Introduction Ageing is a common problem of modern societies, although ocular ageing starts earlier than physiological one. Ocular ageing problems start around the age of 45 with presbyopia. As years pass by, more and
degradation or the degradation of SQSTM1/p62 ( 23 ). A decrease in activity of the autophagic process is a shared characteristic of nearly all aged organisms, which may have a causative role in the functional deterioration of biological systems during
of AD to date, only aducanumab potentially slows the progression of AD [ 1 ]. Many risk factors have been identified contributing to the onset and development of cognitive impairment and dementia, including age, genetics, cardiovascular and cerebral
