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Acta Microbiologica et Immunologica Hungarica
Authors:
F. Kerek
,
G. Szegli
,
Lidia Cremer
,
Andreea-Roxana Lupu
,
Steliana Durbaca
,
Ana Calugaru
,
Aurora Herold
, and
D. Radu

Influence of the novel arthritis drug-substance MCS-18 on the antibody (Ab) production against tetanus toxoid (TT) and diphtheria toxoid (DT) antigens was tested in vivo . Possible involvement of MCS-18 in Toll-like receptor (TLR) signalling pathway was further considered.Materials and methods: Immunization of male CD1 mice was done with subcutaneous injection of TT emulsified in Freund’s Complete (FCA) or Incomplete Adjuvant (FIA) and mixed diversly with MCS-18 and different test substances. To investigate the influence of TLR activation Pam3Cys and lipopolysaccharide (LPS) emulsified in FIA were tested in combinations with MCS-18. Antibody production was analysed in vivo by tetanus-or diphtheria-toxin neutralization test.Results: Immunogenicity of TT was significantly enhanced if administered together with FCA or TLR agonists Pam3Cys or LPS emulsified in FIA. It was shown that MCS-18 attenuated strongly the production of anti-TT Ab if administered together with the Ab elicitor FCA or TLR agonists in various combinations. MCS-18 was also active via oral administration.Discussion: These findings suggest that MCS-18 could be a potent, non-toxic antagonist or a down-regulator of TLR signalling pathway. Investigations on further models are needed to establish if MCS-18 may influence particularly the production of RA-specific auto-antibodies, too.

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occurs partly through inhibition of aurora A. Mol Pharmacol 80(4), 638–646 (2011) Su C.L. Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells

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The development of stress drives a host of biological responses that include the overproduction of a family of proteins named heat shock proteins (HSPs), because they were initially studied after heat exposure. HSPs are evolutionarily preserved proteins with a high degree of interspecies homology. HSPs are intracellular proteins that also have extracellular expression. The primary role of HSPs is to protect cell function by preventing irreversible protein damage and facilitating molecular traffic through intracellular pathways. However, in addition to their chaperone role, HSPs are immunodominant molecules that stimulate natural as well as disease-related immune reactivity. The latter may be a consequence of molecular mimicry, generating cross-reactivity between human HSPs and the HSPs of infectious agents. Autoimmune reactivity driven by HSPs could also be the result of enhancement of the immune response to peptides generated during cellular injury and of their role in the delivery of peptides to the major histocompatibility complex in antigen-presenting cells. In humans, HSPs have been found to participate in the pathogenesis of a large number of diseases. This review is focused on the role of HSPs in atherosclerosis and essential hypertension.

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: ArSV-1 – Arabuta snake virus 1, ArBV-1 – Aramboia boa virus 1, ABV - Aurora borealis virus, BSV-1 – Bis spoeter virus, CASV – California Academy of Science Virus, FStV-1 - Frankfurter Strasse virus 1, GauV-1 – Gaucho virus 1, GOGV – Golden Gate virus

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, Aurora, CO, 4 Department of Radiation Oncology, Stanford University, Stanford, CA, 5 Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA, 6 Division of Oncology, Department of Medicine, Stanford University

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Orvosi Hetilap
Authors:
Anita Stréhn
,
László Szőnyi
,
Gergely Kriván
,
Lajos Kovács
,
György Reusz
,
Attila Szabó
,
Imre Rényi
,
Gábor Kovács
, and
Antal Dezsőfi

antibody in pediatric renal transplant patients. Pediatr. Int., 2008, 50 (4), 454–458. Benden, C., Aurora, P., Burch, M., et al.: Monitoring of Epstein-Barr viral load in pediatric heart and lung transplant recipients

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Narla, V., Blaha, M. J., Blumenthal, R. S. és mtsai: The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences. Vasc. Health Risk Manag., 2009, 5 , 1033

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Journal of Behavioral Addictions
Authors:
Thomas McLaughlin
,
Kenneth Blum
,
Marlene Oscar-Berman
,
Marcelo Febo
,
Gozde Agan
,
James L. Fratantonio
,
Thomas Simpatico
, and
Mark S. Gold

References Aurora , R. N. , Zak , R. S. , Auerbach , S. H. , Casey , K. R. , Chowduri , S. , Krippot , A. , Maganti , R. K. , Ramar , K. , Kristo , D. A

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Parkinson disease: a randomized controlled trial. Mov. Disord., 2007, 22 (14), 2070–2076. 53 Aurora, R. N., Kristo, D. A., Bista, S. R., et al.: The treatment of

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position sensors, a pulse oximeter, a nasal flow thermistor (for measuring snoring), and thoracic and abdominal respiration sensors. Ag/AgCl EEG cup electrodes were fixed with Ten20 EEG conductive paste (Weaver and Company, Aurora, CO, USA). Hardware

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