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Acta Physiologica Hungarica
Authors:
Simona Clichici
,
T. Mocan
,
A. Filip
,
A. Biris
,
S. Simon
,
D. Daicoviciu
,
N. Decea
,
A. Parvu
,
R. Moldovan
, and
A. Muresan

Single-walled carbon nanotubes (SWCNTs) have been proposed for various medical applications. However, their safety for human administration has not been yet fully demonstrated. In vitro studies have pointed oxidative stress as a mechanism involved in their cytotoxic effects. In the present study we have evaluated the capacity of DNA functionalized SWCNTs to induce oxidative stress in blood after intraperitoneal (ip) administration in rats. The presence of SWCNTs in blood was confirmed by Raman spectroscopy 30 minutes after their ip administration. Oxidative stress parameters (malondialdehyde — MDA, protein carbonyls — PC, antioxidant capacity measured as hydrogen donating capacity — HD, sulfhydryl groups — SH, glutathione — GSH and nitrites — NO) were assessed in blood at 3, 6, 24, respectively, and 48 hours after ip injection. MDA, PC and NO exhibited a significant increase at 3-6 hours interval from exposure, followed by a recovery trend. The levels of HD reached a bottom level at 6 hours after administration, while SH strongly decreased at 3 hours interval and increased slightly up to 48 hours without attending the initial values. GSH level recorded an increasing tendency at the 3rd hour, an incomplete recovery process at 24 hours followed by a secondary significant increase following a 48-hour interval. Significant inverse correlations were obtained between the PC and SH levels and between the NO and HD values. In conclusion, the ip administration of DNA functionalized SWCNT in rats results in oxidative stress generation in plasma, with a transient pattern of evolution.

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Acta Microbiologica et Immunologica Hungarica
Authors:
Éva Kiss-Tóth Dojcsák
,
Zoltán Ferenczi
,
Adrienn Szalai Juhász
,
Emőke Kiss-Tóth
,
Olivér Rácz
, and
Bertalan Fodor

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Clinical and Experimental Medical Journal
Authors:
Lidija Mrakovcic
,
Marina Cindric
,
Neven Zarkovic
,
Suzana Borovic Sunjic
,
Andrea Mogus Milankovic
, and
Renate Wildburger

-Hydroxynonenal as a bioactive marker of pathopysiological processes Mol. Aspects Med. 24 281 – 291 . [32]. M. P. Mattson R. C. Haddon A. M. Rao 2000 Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth

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Orvosi Hetilap
Authors:
Tamara Horváth
,
András Papp
,
Mónika Kiricsi
,
Nóra Igaz
,
Vivien Trenka
,
Gábor Kozma
,
László Tiszlavicz
,
Zsolt Rázga
, and
Tünde Vezér

of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells. Part Fibre Toxicol

Open access
Interventional Medicine and Applied Science
Authors:
Anand Maurya
,
Anurag Kumar Singh
,
Gaurav Mishra
,
Komal Kumari
,
Arati Rai
,
Bhupesh Sharma
,
Giriraj T. Kulkarni
, and
Rajendra Awasthi

nanospheres [ 18 ] Carbon nanotubes Cyclo-(D-tryptophan-tyrosine) peptide The developed carbon nanotubes delivered gene to the duodenum, stomach, liver, and kidney via

Open access