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Plant drug mixtures are widely used in the adjuvant therapy of type 2 diabetes mellitus for the prevention of complications. The drug mixtures generally contribute to the efficiency of the therapy and may also reduce undesirable side effects. Two herbal extracts (lyophilized aqueous extracts of plant drug mixtures 1: Myrtilli folium, Phaseoli fructus sine seminibus and 2: Myrtilli folium, Phaseoli fructus sine seminibus, Salviae folium ) were investigated in in vitro rat models. The content of bioactive constituents (polyphenol, flavonoid and vitamin C) in plant drug mixtures and lyophilized samples was evaluated. The antioxidant activity of lyophilized extracts was determined by measuring the ferric reducing ability of the plant, Fe 2+ induced lipid peroxidation (LPO) in rat brain homogenates and NADPH (β-nicotinamide adenine dinucleotide phosphate reduced form) induced LPO in cerebral microsomes. The antioxidant activity of lyophilized extracts was compared to that of quercetin and rutin. Both teas of lyophilized extracts had significant reducing ability (2694 and 2771 μmol/l) and inhibited LPO (IC 50 28.0 and 20.6 μl in NADPH induced LPO, 17.3 and 8.7 μl in Fe 2+ induced LPO). The high concentration of polyphenol/flavonoid (12.38–13.00 and 1.45–5.22 g/100 g, respectively) and vitamin C (0.099–0.165 g/100 g) in the herbal extracts is related to their significant antioxidant properties. The tea mixtures have significant nutritional value, since the consumption of 2 or 3 cups of tea a day covers 50% of the daily requirement of vitamin C and it is also relevant polyphenol source. The high polyphenol/flavonoid content may restore the redox imbalance and contribute to the prevention of diabetic complications.

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Albrecht, M., Bánoczy, J., Dinya, T., Tamás, G. Jr. (1992) Occurrence of oral leukoplakia and lichen planus in diabetes mellitus. J. Oral Path. Med. 21 , 364-366. Occurrence of oral leukoplakia and lichen planus in diabetes

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., Hou, W. C. & Huang, C. L. (2004): Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. J. agric. Fd Chem. , 52 , 1385-1389. Antioxidant effects of chromium supplementation

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factors for mutagenesis, carcinogenesis, and diabetes mellitus ( Negre-Salvayre et al., 2009 ). The amino groups of DNA bases can react non-enzymatically with reducing sugars, and studies have shown that in vivo deoxyguanosine is the most reactive

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) Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control. Clin. Biochem. 34 , 64–70. Işımer A. Oxidative stress and nitric oxide

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Agrawal, P., Rai, V., Singh, R. B. (1996) Randomized placebo controlled, single blind trial of holy basil leaves in patients with non-insulin dependent diabetes mellitus. Int. J. Clin. Pharmacol. Therap. 34

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Acta Biologica Hungarica
Authors:
G. Koricanac
,
Mojca Stojiljkovic
,
Snezana Radivojsa
,
Zorica Zakula
,
Nevena Ribarac-Stepic
, and
Esma Isenovic

hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol. Endocrinol. 18 , 1346–1353. Schutz G. Inactivation of the glucocorticoid receptor in

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Acta Biologica Hungarica
Authors:
Hamadi Fetoui
,
Hanen Bouaziz
,
Amira Mahjoubi-Samet
,
L. Soussia
,
F. Guermazi
, and
Najiba Zeghal

., Mathias, P. C. F. (1996) Undernutrition during early lactation as an alternative model to study the onset of diabetes mellitus type II. Res. Com. Mol. Path. Pharm. 92 , 73-84. Undernutrition during early lactation as an

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Acta Biologica Hungarica
Authors:
Klára Szentmihályi
,
Ilona Szöllősi Varga
,
Anita Gergely
,
Mária Rábai
, and
Mária Then

. , Jasztrab , S. , Ladó , K. , Then , M. ( 2010 ) Inhibition of lipid peroxidation of herbal extracts (obtained from plant drug mixtures of Myrtillifolium , Phaseoli fructus sine seminibus and Salviae folium ) used in type 2 diabetes mellitus

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Acta Biologica Hungarica
Authors:
Márta Kotormán
,
Alexandra Varga
,
Phanindra Babu Kasi
, and
János Nemcsók

, K. ( 2011 ) Coffee components inhibit amyloid formation of human islet amyloid polypeptide in vitro: possible link between coffee consumption and diabetes mellitus . J. Agric. Food Chem. 59 , 13147 – 13155 . 4

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