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Hogyan szabályozza az erythropoesis igénye a vasháztartást?
Regulation of iron homeostasis by the need of erythropoesis
as a sensitive biomarker to detect stimulation of erythropoesis. Drug Test Anal. 2020; 12: 261–267.
A szerző új, a vörösvérsejt hemoglobintartalmára alapozott algoritmust mutat be. A rendszer nem az anaemia kórtanán, hanem a vörösvérsejtképzés eltérésein alapul. Egy vörösvértestben átlag 28–35 pikogramm hemoglobin van. Ha a hemoglobinképzés bármely eleme sérül, a hemoglobintartalom kevesebb mint 28 pikogrammra csökken és hipokróm anaemia jön létre. Ha a vörösvérsejt nukleinsav-anyagcseréje sérül, akkor egy vörösvértest hemoglobintartalma 36 pikogramm vagy több, és hiperkróm anaemia alakul ki. A 28 és 35 pikogramm közötti hemoglobintartalmú normokróm anaemiát az erythropoesis proliferációs eltérései hozhatják létre. A fenti 3 kategória alapján egységes rendszer alkotható és az alapvető laboratóriumi vizsgálatok, illetve a betegek kivizsgálási útjai is modellálhatók. Orv. Hetil., 2014, 155(10), 376–382.
The aim of this study was to evaluate the nutritional status of elderly belonging to one primary care office. Twenty-seven men and 26 women, all over 60 years, were involved. Nutritional assessment, anthropometric measurements were performed, serum proteins, lipid and iron status and haematological parameters were determined. Energy and protein intake was sufficient, but the distribution of energy with a high fat and low carbohydrate was inadequate. Iron, copper, calcium, retinol and folate intake was lower, whereas sodium, ascorbic acid and cobalamin intake was higher than the Hungarian recommendation. The prevalence of obesity characterized by body mass index or waist circumference was higher in women than in men. The percentage of pathological levels of lipid parameters was also higher in women. No iron deficient erythropoesis was detected, but high serum ferritin concentration as a marker of body iron store was determined in some cases. General practitioners have possibilities to influence the nutritional habits of elderly, thereby reducing the incidence of obesity, cardiovascular diseases and stroke. Iron status of Hungarian elderly looks to be satisfactory, so supplementation without testing the iron status would be useless and harmful.
