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European Journal of Microbiology and Immunology
Authors:
Manja Boehm
,
Daniel Simson
,
Ulrike Escher
,
Anna-Maria Schmidt
,
Stefan Bereswill
,
Nicole Tegtmeyer
,
Steffen Backert
, and
Markus M. Heimesaat

adhesion to fibronectin (CadF) [ 23 , 24 ], major outer membrane protein (MOMP) [ 25 ], periplasmic binding protein (PEB1) [ 26 ], P95 [ 27 ], jejuni lipoprotein A (JlpA) [ 28 , 29 ], Campylobacter autotransporter protein A (CapA) [ 30 ], and

Open access
Acta Biologica Hungarica
Authors:
Arda Örçen
,
Vuslat Yilmaz
,
Murat Giriş
,
Uğur Akcan
,
Erdem Tüzün
, and
Gaye Erten

, E. , Kometani , M. , Tozaki-Saitoh , H. , Inoue , K. ( 2009 ) Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways . J. Cell. Mol. Med. 13

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atmosphere. The following day, potential growth inhibition zones around the discs were scrutinized by macroscopic inspection. For assessment of biofilm formation, experiments were performed in 96-well microtiter plates coated with human fibronectin

Open access
Acta Biologica Hungarica
Authors:
L. M. Jesus
,
P. R. C. Abreu
,
Marcela C. Almeida
,
Lavínia C. Brito
,
Sheila F. Soares
,
D. E. De Souza
,
Luciana C. Bernardo
,
A. S. Fonseca
, and
M. Bernardo-Filho

., Bernardo-Filho, M., Meirelles, M. N., Tournier, J. M., Puchelle, E. (1993) Pseudomonas aeruginosa binds to soluble cellular fibronectin. Current Microbiol. 26 , 91-95. Current Microbiol

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European Journal of Microbiology and Immunology
Authors:
Ahmed Elfiky
,
Agnes Bonifacius
,
Joern Pezoldt
,
Maria Pasztoi
,
Paweena Chaoprasid
,
Pooja Sadana
,
Nagla El-Sherbeeny
,
Magda Hagras
,
Andrea Scrima
,
Petra Dersch
, and
Jochen Huehn

Arencibia I , Suarez NC , Wolf-Watz H , Sundqvist KG . Yersinia invasin, a bacterial beta1-integrin ligand, is a potent inducer of lymphocyte motility and migration to collagen type IV and fibronectin . J Immunol . 1997

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European Journal of Microbiology and Immunology
Authors:
Jana Niemz
,
Stefanie Kliche
,
Marina C. Pils
,
Eliot Morrison
,
Annika Manns
,
Christian Freund
,
Jill R. Crittenden
,
Ann M. Graybiel
,
Melanie Galla
,
Lothar Jänsch
, and
Jochen Huehn

Using quantitative phosphopeptide sequencing of unstimulated versus stimulated primary murine Foxp3+ regulatory and Foxp3 conventional T cells (Tregs and Tconv, respectively), we detected a novel and differentially regulated tyrosine phosphorylation site within the C1 domain of the guanine-nucleotide exchange factor CalDAG GEFI. We hypothesized that the Treg-specific and activation-dependent reduced phosphorylation at Y523 allows binding of CalDAG GEFI to diacylglycerol, thereby impacting the formation of a Treg-specific immunological synapse. However, diacylglycerol binding assays of phosphomutant C1 domains of CalDAG GEFI could not confirm this hypothesis. Moreover, CalDAG GEFI−/− mice displayed normal Treg numbers in thymus and secondary lymphoid organs, and CalDAG GEFI−/− Tregs showed unaltered in vitro suppressive capacity when compared to CalDAG GEFI+/+ Tregs. Interestingly, when tested in vivo, CalDAG GEFI−/− Tregs displayed a slightly reduced suppressive ability in the transfer colitis model when compared to CalDAG GEFI+/+ Tregs. Additionally, CRISPR-Cas9-generated CalDAG GEFI−/− Jurkat T cell clones showed reduced adhesion to ICAM-1 and fibronectin when compared to CalDAG GEFI-competent Jurkat T cells. Therefore, we speculate that deficiency in CalDAG GEFI impairs adherence of Tregs to antigen-presenting cells, thereby impeding formation of a fully functional immunological synapse, which finally results in a reduced suppressive potential.

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C.R. Young 1999 The absence of cecal colonization of chicks by a mutant of Campylobacter jejuni not expressing bacterial fibronectin-binding protein Avian Dis

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931 Euker TP, Konkel ME: The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating

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ME Konkel 2012 The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling

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.M. Overall 1998 The involvement of the fibronectin type II-like modules of human gelatinase A in cell surface localization and activation J Biol Chem 273 32

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