Authors:Markus M. Heimesaat, Gernot Reifenberger, Viktoria Vicena, Anita Illes, Gabriella Horvath, Andrea Tamas, Balazs D. Fulop, Stefan Bereswill, and Dora Reglodi
Pituitary adenylate cyclase activating polypetide (PACAP) constitutes a neuropeptide that is widely distributed in the host exerting essential cytoprotective properties, whereas PACAP−/− mice display increased susceptibility to distinct immunopathological conditions. The orchestrated interplay between the gut microbiota and the host is pivotal in immune homeostasis and resistance to disease. Potential pertubations of the intestinal microbiota in PACAP−/− mice, however, have not been addressed so far. For the first time, we performed a comprehensive survey of the intestinal microbiota composition in PACAP−/− and wildtype (WT) mice starting 2 weeks postpartum until 18 months of age applying quantitative culture-independent techniques. Fecal enterobacteria and enterococci were lower in PACAP−/− than WT mice aged 1 month and ≥6 months, respectively. Whereas Mouse Intestinal Bacteroides were slightly higher in PACAP−/− versus WT mice aged 1 and 6 months, this later in life held true for Bacteroides/Prevotella spp. (≥12 months) and lactobacilli (>15 months of age). Strikingly, health-beneficial bifidobacteria were virtually absent in the intestines of PACAP−/− mice, even when still breastfed. In conclusion, PACAP deficiency is accompanied by distinct changes in fecal microbiota composition with virtually absent bifidobacteria as a major hallmark that might be linked to increased susceptibility to disease.
Authors:Ulrike Escher, Eliezer Giladi, Ildikò R. Dunay, Stefan Bereswill, Illana Gozes, and Markus M. Heimesaat
It is tempting to speculate whether the observed anti-inflammatory effects of NAP might have been even more pronounced upon increases in dosage and/or application frequencies of the synthetic compound or upon a prophylactic
Authors:Markus M. Heimesaat, Ulrike Escher, Anne Grunau, Ulrike Fiebiger, and Stefan Bereswill
should be investigated in the future to gain deeper insights into the interactions within the gut–brainaxis in health and disease.
In conclusion, we here present a low-dose T. gondii -induced non-lethal subacute
Authors:H. Soltanmoradi, M.S. Maniati, A. Davoodabadi, A. Mosapour, S. Samavarchi Tehrani, M. Pazhoohan, F. Daemi, and H. Khaleghzadeh-Ahangar
microbiota-gut-brainaxis by probiotics in a murine model of inflammatory bowel disease . American Journal of Physiology – Gastrointestinal and Liver Physiology , 310 ( 11 ): G989 – G998 . 10.1152/ajpgi.00086.2016 Furness , J.B. ( 2012 ). The enteric
Authors:Ke Du, Stefan Bereswill, and Markus M. Heimesaat
. The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brainaxis? Neurochem Int 2016 ; 99 : 110 – 32 . https://doi.org/10.1016/j.neuint.2016.06.011 . 10.1016/j.neuint.2016.06.011 13. Arpaia N , Campbell C , Fan X