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Journal of Radioanalytical and Nuclear Chemistry
Authors:
Zhang Shuyan
,
Wang Xizhong
,
Wang Zishu
,
Cheng Wenyuan
,
Jin Jianan
,
Zhang Jiazao
,
Xu Daoquan
,
Shao Yuesheng
,
Luo Changrong
,
Wang Juan
,
Wu Kejia
, and
Zhou Maolun

Abstract  

Na2 1 1At and2 1 1At–Te colloid injections were prepared. By comparison with tissue distribution of Na2 1 1At and2 1 1At–Te colloid injections it has been demonstrated that the2 1 1At–Te colloid is stable in vivo. It has been shown that the radiohalogen,2 1 1At, has huge and extensive radiobiological effects in studying on the changes in histopathology, enzyme histochemistry, chromosome aberration, micronucleus frequency of bone-marrow polychromatic erythrocytes and the injury effect of2 1 1At on experimental Ehrlich ascites cells.

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Summary  

Radioanalytical techniques have been applied in a study on (subclinical) hepatitis in Dobermann dogs. Cu levels in transcutaneous obtained full liver biopsies were quantified using INAA and 66Cu. A copper excretion study was performed in a group of completely normal Dobermann dogs and in six Dobermanns with elevated copper levels and suffering from subclinical hepatitis. 64Cu2+ was used to assess whether a normal bile flow and thus excretion was possible. All subjects underwent separately from this 64Cu2+ excretion study a 99mTc-Bis-IDA scintigraphy. The Cu levels in liver of these hepatitis patients vary from 600 to 1600 mg . kg-1 whereas 100-300 mg . kg-1 is probably normal for healthy Dobermann dogs. These Cu levels match fully with histopathology results and clinical observations. Measurements during a 2 years' evaluation period showed a clear relation between the existence of subclinical hepatitis and increased Cu levels without a sign for cholestasis or an abnormal bile flow.

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