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Soy is increasingly used as a food additive. In women, it is recommended as an alternative to hormonal replacement therapy and/or a preventive agent against breast cancer and osteoporosis. Previous data revealed that rats fed on raw soybean diet developed pancreas hypertrophy and hyperplasia. An animal model was used in our experiment to examine the effects of raw soybean on parotid gland of rats. The purpose of this study was to light on the role of different neuropeptide-containing nerve fibres on changes in the acinar cells. The morphological structure and the neuropeptide-containing nerve fibers (NPY, GAL, SOM, SP, CGRP, VIP) of the glands were examined by light and electronmicroscopy. Significant increase of the organ weight was detected in the animals fed by raw soybean compared to control samples. Changes in the number of different neuropeptide-containing nerve fibres were various: Significant decrease in the NPY-immunoreactive (IR) and significant increase in the GAL-IR nerve fibres were observed. Slight but not significant increase in VIP-IR; and no changes in the other IR nerve fibres were found. The electronmicroscopic alterations of acinar cells were manifest, where a large number of undifferentiated glandular cells were seen among the acini. Some of these cells contained two nuclei and their cytoplasm contained only a few secretory granules. These granules were similar to those in the mucous cells but not to the serous ones. The results presented here provide direct morphological evidence for the role of raw soy on the density of different neuropeptide-containing nerve fibres inducing proliferation in the acinar cells of parotid glands from rats. It is suggested that the hypertrophic changes in the glands might be caused by the alterations of nerve fibres.

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Bayes-Genis, A., Cambell, J., Carlson, P., Holmes, D. R. Jr., Schwartz, R. S. (2002) Macrophages, myofibroblasts and neointimal hyperplasia after coronary artery injury and repair. Atherosclerosis 163 , 89

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In Vitro 15 351 355 Wynford-Thomas, D., Stringer, B. M. (1982) Mast cell hyperplasia during goitrogen

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1177 Ulrich-Lai, Y. M., Figueiredo, H. F., Ostrander, M. M., Choi, D. C., Engeland, W. C., Herman, J. P. (2006) Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion

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Kenny, B., Ballard, S., Blagg, J., Fox, D. (1997) Pharmacological options in the treatment of benign prostatic hyperplasia. J. Med. Chem. 40 , 1293–1315. Fox D. Pharmacological

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from Ligularia fischeri and their hyperplasia inhibition activity of cancer cell . J. Biol. Environ. Cont. 18 , 67 – 73 . 2. Boyle , S. P. , Dobson , V. L. , Duthie

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S. Falkow 1993 Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia Infect Immun 61

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. DB Schauer S Falkow 1993 Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia

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European Journal of Microbiology and Immunology
Authors:
Libo Zheng
,
Xiaolan Zhang
,
Jeremy Chen
,
Ryan Ichikawa
,
Kori Wallace
,
Charalabos Pothoulakis
,
Hon Wai Koon
,
Stephan R. Targan
, and
David Q. Shih

2011 Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia Mucosal Immunol 4 186 196

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( Kennedy, 2005 ; Clemente et al., 2010 ). This biomolecule was demonstrated for its efficacy against oral leukoplakia ( Armstrong et al., 2013 ), prostatic hyperplasia ( Malkowicz et al., 2001 ), and colorectal cancer ( Clemente & Arques, 2014

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