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Introduction Drugs, as molecules of non-natural chemical character for the human, are subjected to processes of absorption, distribution, metabolism, and excretion (known as ADME), regardless of the route of their

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Introduction Metabolism can be described as the set of chemical reactions that take place within the cell and involve energy flow and participation of certain enzymes. It consists of two fundamental processes: (a) Catabolism

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Abstract  

Power-time curves and metabolic properties of Tetrahymena thermophila BF5 exposed to different Yb3+ levels were studied by ampoule method of isothermal calorimetry at 28°C. Metabolic rate (r) decreased significantly while peak time (PT) increased with the increase of Yb3+. These results were mainly due to the inhibition of cell growth, which corresponded to the decrease of cell number obtained by cell counting. Compared with cell counting, calorimetry was sensible, easy to use and convenient for monitoring the toxic effects of Yb3+ on cells and freshwater ecosystem. It was also found that cell membrane fluidity decreased significantly under the effects of Yb3+, which indicated that Yb3+ could be membrane active molecules with its effect on cell membranes as fundamental aspect of its toxicity.

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(liberation, absorption, distribution, metabolism, and excretion). One of the many important issues associated with the creation of a new molecular entity is to investigate the pathways of the metabolism. The vast majority of drugs are metabolized commonly in

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Abstract  

The effect of Cr(VI) on Desulfovibrio vulgaris strain Hildenborough bioenergetic metabolism was monitored by microcalorimetry and the concomitant reduction of this metal was studied. Results showed that Cr(VI) is reduced by the bacterium and that the bacterial growth is altered, involving a strong modification of the metabolism of the bacteria. An absence of correlation between Cr(VI) reduction and cell growth is observed, suggesting that Cr(VI) does not yield energy to support anaerobic growth. The analysis of the enzymatic characteristics of Cr(VI) reduction are in progress.

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, anti-progesterone, anti-schistosome, anti-toxoplasma, anti-arrhythmic, anti-fiber role, and so on [ 4 – 6 ]. In this project, the extent and duration of the inhibitory effect on the metabolism of E. coli were judged from the rate constant k [ 5

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Abstract  

Metabolism of acetochlor /2-chloro-N-/2-ethyl-6-methyl-phenyl/-N-/ethoxymethyl/acetamide/ herbicide was traced in tolerant corn /Zea mays L./ and sensitive wheat /Triticum aestivum L./. Both resistant and susceptible plant species were found to have the ability to metabolize acetochlor absorbed. However, a faster metabolism of the herbicide was observed in the tolerant plants.

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Summary  

The time dependences of the thermal power of aqueous myoglobin solutions were measured by microcalorimeter at 298.15 K. Exothermic reactions occurred in aqueous myoglobin solutions due to the metabolism of aerobic microbes, and these roughly consisted of four phases. The generation times obtained were about (555) min for the logarithmic exothermal reaction phase. The total energies were considerably dependent on the amount of oxygen present, suggesting strongly that the exothermic reaction was caused by aerobic microbes. The apparent thermal metabolic rates were positively dependent on the concentration of myoglobin, probably because of the effects of myoglobin as a food source and/or as a donor of oxygen.

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References [1] P.R . Bieck (Ed.) Colonic Drug Absorption and Metabolism , Marcel Dekker , New York , 1993 . [2] B . Fried and J . Sherma , Thin-Layer Chromatography , 4th edn , Marcel Dekker , New York , 1999 . [3] C.F . Poole , J

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