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References 1. Crawford J , Dale DC , Lyman GH : Chemotherapy-induced neutropenia: risks, consequences, and new direction for its

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743 752 Hathorn, J. W., Lyke,. K. (1997) Empirical treatment of febrile neutropenia: evolution of current therapeutic approaches. Clinical Infectious Diseases 24 , (Suppl. 2

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Harless, W., Crowell, E., Abraham, J. (2006) Anemia and neutropenia associated with copper deficiency of unclear etiology. Am. J. Hematol. 81 , 546–549. Abraham J. Anemia and

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therapy or acquired immunosuppression (e.g., HIV-infection, severe neutropenia), mechanical ventilation, dialysis, patients with chronic illnesses (e.g., diabetes, respiratory disorders) or cancer, or a developmental abnormality [ 30 ]. Prevention of S

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disruption of physical barriers) and intensive cytotoxic chemotherapy regimens (causing profound neutropenia); in these cases, the normal microflora of the patients may enter into the bloodstream, causing bacteremia [ 48, 49, 82 ]. In the clinical study of

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infections diseases such as psoriasis [ 101 ], atopic dermatitis [ 102 ], rosacea [ 103 ], Kostmann's syndrome [ 104 ], severe congenital neutropenia [ 105 ], lupus erythematodes [ 106 ], acne vulgaris [ 107 ], folliculitis [ 108 ], scleroderma [ 109

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. Melis D , Della Casa R , Parini R , Rigoldi M , Cacciapuoti C , Marcolongo P , Vitamin E supplementation improves neutropenia and reduces the frequency of infections in patients with glycogen storage disease type 1b . Eur J Pediatr

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. Marchetti 2010 Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia J Clin Microbiol

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bacterial and fungal pathogens in febrile neutropenia Journal of Clinical Microbiology 47 2405 2410 . 106. N

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European Journal of Microbiology and Immunology
Authors: Hagen Frickmann, Thomas Köller, Ralf Matthias Hagen, Klaus-Peter Ebert, Martin Müller, Werner Wenzel, Renate Gatzer, Ulrich Schotte, Alfred Binder, Romy Skusa, Philipp Warnke, Andreas Podbielski, Christian Rückert, and Bernd Kreikemeyer

Song Y Öhrmalm L Giske CG . Metagenomic analysis of bloodstream infections in patients with acute leukemia and therapy-induced neutropenia . Sci Rep . 2016 ; 6 : 23532 . 10.1038/srep23532 53. Schmidt K

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