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Abstract  

Differential scanning microcalorimetry (DSC) and UV–VIS absorption spectroscopy were used to obtain the characteristics of blood serum from newborn rat’ after maternal treatment with cyclophosphamide in comparison with control. The obtained DSC curves reveal a complex endothermic peak due to the unfolding process of various serum proteins. Thermal profiles and absorption spectra of blood serum are sensitive to the age of newborns as well as to effect of maternal administration of cyclophosphamide. The most significant disturbances in serum proteome were observed for 14-day old newborns. The thermodynamic parameters: enthalpy change (∆H), the normalized first moment (M1) of the thermal transition with respect to the temperature axis and the ratio of C p ex at 70 and 60 °C describing denaturation contributions of globulin forms in respect to unliganded albumin with haptoglobin was estimated. Moreover, the second derivative spectroscopy in the UV region was used to resolve the complex protein spectrum. The differences in blood serum detected by DSC and UV–VIS confirm a potential usefulness of these methods for diagnostic and monitoring changes with age as well as the pathological state of blood serum.

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smoking. The aim of the present study was to investigate the influence of maternal smoking during pregnancy on the early physical and neurobehavioral development of newborn rats. Our hypothesis was that maternal smoking during pregnancy interferes with

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. J., et al.: Glucagon-like-peptide-1 and exendin-4 stimulate β-cell neogenesis in streptozotocin-treated newborn rats resulting in presistenly improved glucose homeostasis at adult age

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1991; 66: 153–156. 36 Nagy SU, Csaba G. Dose dependence of the thyrotropin (TSH) receptor damaging effect of gonadotropin in the newborn rats. Acta Physiol Hung. 1980; 56: 417

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of TSH and gonadotropin pretreatment (hormonal imprintig) of newborn rats on hormonal overlap in adult animals. Acta Physiol Hung. 1983; 61: 205–211. 10

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., Gyenge, M., Hantos, M., et al.: Transgenerational hormonal imprinting caused by vitamin A and vitamin D treatment of newborn rats. Alterations in the biogenic amine contents of the adult brain. Brain Dev., 2009

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1355 1363 Tekes, K., Gyenge, M., Hantos, M. és mtsai: Transgenerational hormonal imprinting caused by vitamin A and vitamin D treatment of newborn rats

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Tekes, K., Gyenge, M., Hantos, M., et al.: Transgenerational hormonal imprinting caused by vitamin A and vitamin D treatment of newborn rats. Alterations in the biogenic amine contents of the adult brain. Brain Dev., 2009, 31 , 666

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, Jacques Miller removed the thymus from newborn rats, which caused a dramatic effect on the condition and immunity of the animals [2] , as a part of the lymphocyte population (later named T cells) disappeared and a fatal wasting disease developed. Further

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