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prescription-only medicines can lead to a variety of health risks that present a serious risk, such as cardiovascular disease, liver disease, kidney failure, agitation, anxiety, confusion, depression, etc. For this reason, the World Health Organization (WHO

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Acta Chromatographica
Authors: Chen Cheng, Nie Cun-Xi, Liang Jing, Wang Yong-Qiang, Liu Yan-Feng, Ge Wen-Xia, and Zhang Wen-Ju

undetectable since it was over covered by acetone signal peak. The method had been abandoned because of the anxiety about the proceeding loss of few remaining amount of gossypol during the process. The antioxidant NADPH-Na 4 [ 17 , 18 ] or glutathione

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Summary

Scutellaria L. is a diverse genus of the Lamiaceae (Labiatae) family of over 300 herbaceous plants commonly known as skullcaps. Various species of Scutellaria are used as ethnobotanical herbs for the treatment of ailments like cancer, jaundice, cirrhosis, anxiety, and nervous disorders. Scutellaria incana L., commonly known as the Hoary skullcap, is a traditional medicinal plant used by native Americans as a sedative for nervousness or anxiety. S. incana metabolites were identified by comparing their high-performance liquid chromatography (HPLC) retention times and mass spectra with those of the corresponding authentic standards. Where standards were unavailable, the structures were characterized on the basis of their tandem mass spectrometry (MS/MS) spectra following collision-induced dissociation (CID) and the accurate masses of the corresponding deprotonated molecules [M-H] (mass accuracy ± 5 ppm). A total of 40 flavonoids, including two phenolic glycosides, were identified from leaves, stems, and roots of S. incana. Differences in the flavonoid composition between leaves, stems, and roots in S. incana were observed although the flavonoid profile of S. incana is consistent with other Scutellaria species. Further work should focus on assessing the potential of S. incana as a source of these bioactive metabolites.

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major alkaloid with more pharmaceutical applications is reserpine, which is used mostly for the treatment of hypertension [ 15 ], treatment of insomnia, cardiovascular diseases, anxiety and other mental disorders [ 16 ]. An alkaloid known as

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[ 25, 26 ]. Psoriasis patients, in addition to suffering from diseases, often also bear a great psychological burden and are prone to anxiety, inferiority, self-injury, and even depression, which affects quality of their life seriously [ 27 ]. The

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