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Introduction Nitric oxide (NO) is one of the most important molecules that are responsible for the vasodilator tone required for the regulation of blood pressure [ 1 ]. NO is synthesized from L -arginine by a family of enzymes
Molnár, M., Sütö, T., Tóth, T. és mtsa: Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am. J. Obstet. Gynecol., 1994, 170 , 1458
increasing nitric oxide production, improving inflammation and oxidation, enhancing endothelial progenitor cells migration, and so on which now are referred to as pleiotropic effects ( 4 , 5 , 28 ). Statins are widely used and are the most effective
Some studies suggested a positive effect against cardiometabolic diseases of supplementation of alpha-linolenic acid (ALA, C18:3 n-3) rich foods in pathological subjects, even if the total literature is controversial. In order to clarify ALA-rich chia seed action in hypertensive model with the overt pathology and without drug interference, in the present study the biochemical markers of cardiometabolic diseases (endothelin-1, ET-1; nitric oxide, NO; and bradykinin, BK) in Spontaneously Hypertensive Rats (SHRs) were analysed after 5% chia seed dietary supplementation for five weeks, and compared with the staple raw material wheat and corn. At the end of the experimental period, also plasma antioxidant capacity and inflammatory condition were evaluated. Our results showed that the chia seed group was more oxidized. On the other hand, ET-1 significantly decreased in chia seed group, and there was no difference between groups for NO, BK, and the inflammatory C-reactive protein (CRP). In conclusion, some positive effects of chia seed consumption on cardiometabolic markers in SHRs were observed, despite this the association of chia seeds with antioxidants is suggested to avoid plasma oxidation increase.
), H783– H788. 11 Szekeres, M., Nádasy, G. L., Kaley, G., et al.: Nitric oxide and prostaglandins modulate pressure-induced myogenic responses of intramural
. Xie QW , Whisnant R , Nathan C : Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide . J Exp Med 177 , 1779 – 1784
Kukor, Z., Valent, S.: Nitric oxide and preeclampsia. [A nitrogén-monoxid-szintézis zavarai praeeclampsiában.] Orv. Hetil., 2010, 151 , 2125–2135. [Hungarian] Valent S. Nitric oxide
Minamishima S, Bougaki M, Sips PY, De Yu J, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F: Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice
]. 10 Gebistorf F, Karam O, Wetterslev J, et al. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults. Cochrane Database Syst Rev. 2016; 2016(6): Cd002787. 10
Cancer Research (CECR), Tanta University. Biochemical analysis The level of high-density lipoproteins (HDLs) was determined according to the method described by Burstein et al. [ 13 ]. The concentration of nitric oxide
