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It remains difficult to distinguish adenoid cystic carcinoma (ACC) from polymorphous low-grade adenocarcinoma (PLGA). Although these neoplasms exhibit nearly similar histologic patterns, their biologic behavior is significantly different. This study was carried out in an attempt to overcome the histological overlap between these tumors using immunohistochemical method for c-kit and galectin-3 proteins on twenty cases of salivary gland tumors including twelve ACC and eight PLGA. Results revealed positive cytoplasmic reactivity for c-kit in 100% of ACC cases and only in 25% of PLGA. On the other hand, galectin-3 expression was observed in 100% of both ACC and PLGA cases. Moreover, solid variant of ACC showed overexpression of both proteins than cribriform and tubular subtypes. Significant positive correlation between the two studied proteins in ACC and PLGA was also observed (p < 0.05). Upon these results, over expression of c-kit and galectin-3 in ACC cases supports the concept of solid variant as a high-grade tumor. Moreover, c-kit may be used as a helpful marker to distinguish ACC from PLGA in cases where the diagnosis can be challenging.
., 2007, 71 (10), 959–961. Lu, F., Longo, M., Tamayo, E., et al.: The effect of over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in unrestrained conscious
225 231 Venugopal, S. K., Jiang, J., Kim, T. H, et al.: Liver fibrosis causes down-regulation of miRNA-150 and miRNA-194 in hepatic stellate cells and their over-expression
364 Venugopal, S. K., Jiang, J., Kim, T. H. és mtsai: Liver fibrosis causes down-regulation of miRNA-150 and miRNA-194 in hepatic stellate cells and their over-expression
5430 Skov, B. G., Fischer, B. M., Pappot, H.: Oestrogen receptor beta over expression in males with non-small cell lung cancer is associated with better survival. Lung Cancer
-dependent, chromosomally mediated β-lactamases (L1 and L2) [ 14, 18 ]. In addition, a resistant phenotype may be expressed through a multitude of other mechanisms, e.g., lipopolysaccharide-changes or modifying enzymes for aminoglycosides, or through the over-expression of
Y , Yang P : Multilineage differentiation of dental follicle cells and the roles of Runx2 over-expression in enhancing osteoblast
, C. , Sántha , M. , & Puskás , L. G. ( 2005 ). Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug
, O’Brien ER : Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions . PLoS One 8 , e
