Authors:N. Almási, Z. Murlasits, A. Al-awar, Á. Csonka, S. Dvorácskó, C. Tömböly, S. Török, D. Bester, A. Pósa, C. Varga, and K. Kupai
particularly in constipation and delayed transit time in the elderly. A plethora of evidence suggests that key signs of the aging process, such as loss of neurons in the gut, increase in the amount of aggregated proteins, elevation in oxidativestress and
Authors:András Szarka, Gábor Bánhegyi, and Balázs Sümegi
Fukui, H., Moraes, C. T.: The mitochondrial impairment, oxidativestress and neurodegeneration connection: reality or just an attractive hypothesis? Trends Neurosci., 2008, 31 (5), 251–256.
Lieber, M. R
Authors:S. Hiriyanna Hiriyanna, K. Basavaiah, P. S. Goud Goud, V. Dhayanithi, K. Raju, and H. Pati Pati
Studies of the degradation of olanzapine bulk drug under hydrolytic (acidic and alkaline), oxidising, and photolytic conditions are reported in this paper. Olanzapine is almost completely stable under photolytic and hydrolytic (acidic and alkaline) conditions. The major degradation products formed when olanzapine bulk drug was exposed to oxidative stress conditions were isolated by preparative reversed-phase high-performance liquid chromatography and characterized by FTIR, LC-MS-MS, and 1H, 13C, and DEPT NMR. On the basis of results from spectroscopy the degradation products were characterized as 10-hydroxy-2-methyl-5,10-dihydro-4H-benzo[b]thieno [2,3-e][1,4]diazepin-4-one, 2-methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one, and 2-methyl-10-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4] diazepin-4-yloxy)-5,10-dihydro-4H-benzo[b]thieno[2,3-e]diazepin-4-one. Identification, isolation, and characterization of these oxidative degradation products are discussed in detail.
Authors:Judit Mercédesz Pomothy, Katrina Gatt, Ákos Jerzsele, and Erzsébet Pászti Gere
to apoptosis. Oxidativestress is a phenomenon which occurs in a cell when the concentration of ROS exceeds the antioxidant capacity. ROS can initiate the process of lipid peroxidation causing damage to phospholipids and lipoproteins of the cell
oxidativestress and the high release of free radicals [ 3 ]. Oxidativestress is caused by the imbalance between the production of free radicals and reactive oxygen species on one hand, and antioxidant defense system on the other hand, and can have
Authors:D. Gerszi, Á. Penyige, Z. Mezei, B. Sárai-Szabó, R. Benkő, B. Bányai, C. Demendi, E. Ujvári, S. Várbíró, and E.M. Horváth
biological pathways, where they act as mediators; however, their overproduction leads to oxidative/nitrative stress that takes part in the pathogenesis of numerous diseases [ 9, 10 ]. Oxidativestress increases during the course of physiological pregnancy