Search Results

You are looking at 1 - 10 of 201 items for :

  • "oxidative stress" x
  • Refine by Access: Content accessible to me x
Clear All
Physiology International
Authors: N. Almási, Z. Murlasits, A. Al-awar, Á. Csonka, S. Dvorácskó, C. Tömböly, S. Török, D. Bester, A. Pósa, C. Varga, and K. Kupai

particularly in constipation and delayed transit time in the elderly. A plethora of evidence suggests that key signs of the aging process, such as loss of neurons in the gut, increase in the amount of aggregated proteins, elevation in oxidative stress and

Open access
Acta Veterinaria Hungarica
Authors: Dániel J. Kócsó, Judit Szabó-Fodor, Miklós Mézes, Krisztián Balogh, Szilamér Ferenczi, András Szabó, Brigitta Bóta, and Melinda Kovács

mechanism of cell toxicity . Int. J. Biochem. Cell Biol. 43 , 897 – 904 . El Golli-Bennour , E. and Bacha , H. ( 2011 ): Hsp70 expression as biomarkers of oxidative stress

Open access
Orvosi Hetilap
Authors: András Szarka, Gábor Bánhegyi, and Balázs Sümegi

–902. Fukui, H., Moraes, C. T.: The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis? Trends Neurosci., 2008, 31 (5), 251–256. Lieber, M. R

Open access
Acta Chromatographica
Authors: S. Hiriyanna Hiriyanna, K. Basavaiah, P. S. Goud Goud, V. Dhayanithi, K. Raju, and H. Pati Pati

Summary

Studies of the degradation of olanzapine bulk drug under hydrolytic (acidic and alkaline), oxidising, and photolytic conditions are reported in this paper. Olanzapine is almost completely stable under photolytic and hydrolytic (acidic and alkaline) conditions. The major degradation products formed when olanzapine bulk drug was exposed to oxidative stress conditions were isolated by preparative reversed-phase high-performance liquid chromatography and characterized by FTIR, LC-MS-MS, and 1H, 13C, and DEPT NMR. On the basis of results from spectroscopy the degradation products were characterized as 10-hydroxy-2-methyl-5,10-dihydro-4H-benzo[b]thieno [2,3-e][1,4]diazepin-4-one, 2-methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one, and 2-methyl-10-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4] diazepin-4-yloxy)-5,10-dihydro-4H-benzo[b]thieno[2,3-e]diazepin-4-one. Identification, isolation, and characterization of these oxidative degradation products are discussed in detail.

Full access

to apoptosis. Oxidative stress is a phenomenon which occurs in a cell when the concentration of ROS exceeds the antioxidant capacity. ROS can initiate the process of lipid peroxidation causing damage to phospholipids and lipoproteins of the cell

Open access

oxidative stress and the high release of free radicals [ 3 ]. Oxidative stress is caused by the imbalance between the production of free radicals and reactive oxygen species on one hand, and antioxidant defense system on the other hand, and can have

Open access
Physiology International
Authors: D. Gerszi, Á. Penyige, Z. Mezei, B. Sárai-Szabó, R. Benkő, B. Bányai, C. Demendi, E. Ujvári, S. Várbíró, and E.M. Horváth

biological pathways, where they act as mediators; however, their overproduction leads to oxidative/nitrative stress that takes part in the pathogenesis of numerous diseases [ 9, 10 ]. Oxidative stress increases during the course of physiological pregnancy

Open access

–19. 4 Cousins RJ, Liuzzi JP, Lichten LA. Mammalian zinc transport, trafficking, and signals. J Biol Chem 2006; 281: 24085–24089. 5 McLaren SH, Gao D, Chen L, et al. Oxidative stress and

Open access
Orvosi Hetilap
Authors: Eszter Mária Horváth, Rita Mágenheim, Beatrix Annamária Domján, Viktória Ferencz, Tímea Tänczer, Eszter Szabó, Rita Benkő, Csaba Szabó, Ádám Tabák, and Anikó Somogyi

(9), 1935–1943. 5 Kamath, U. G., Rao, G., Raghothama, C., Rai, L., et al.: Erythrocyte indicators of oxidative stress in gestational diabetes. Acta

Open access

. Cardiol., 2012, 60 (18), 1778–1786. 16 Schulz, E., Jansen, T., Wenzel, P., et al.: Nitric oxide, tetrahydrobiopterin, oxidative stress and endothelial dysfunction in

Open access