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as antihypertensive system, which should be superior in activity, tolerability, or both. Additionally, herbal flavonoid component, i.e., Rutin (Ru, quercetin disaccharide conjugate) is used as bioenhancing agent. The specific goals of the research

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, characterize, and optimize isradipine (ISR; 15%–24% oral bioavailability and poor solubility) with enhancing agent (rutin) loaded nano-colloidal carrier via polymer (Eudragit L100)-coated, i.e., SLNbp using central composite design. Basically in this study

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Acta Chromatographica
Authors: Y.T. Kamal, Sayeed Ahmad, Nanjaian Mahadevan, Prawez Alam, Shahana Salam, Yahya I Asiri, Abdullatif Bin Muhsinah, and Abdulrhman Alsayari

free flavonoids like rutin and quercetin forms the basis of bioactivity of these Itrifal formulations [ 5 ]. The anthraquinone glycosides like sennoside A and B were selected as a specific marker for C. angustifolia , which is present in a significant

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Acta Chromatographica
Authors: Milica Atanacković Krstonošić, Jelena Cvejić Hogervorst, Mira Mikulić, and Ljiljana Gojković-Bukarica

. Experimental 2.1. Standards and Reagents Phenolic standards, namely, rutin, naringenin, chlorogenic acid, trans -cinnamic acid, quercetin, p -coumaric acid, caffeic acid, p -hydroxybenzoic acid, syringic acid, vanillic

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from Sigma-Aldrich, St. Louis (Missouri, USA). Precoated TLC (silica gel 60 F254) and quercetin were purchased from Merck (Darmstadt, Germany). Rutin and β-sitosterol were purchased from Sigma-Aldrich (St. Louis, Missouri, USA). The solvents used for

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.095 Gallic acid 10–1000 0.9965 4.50 9.50 Rutin 1–500 0.9925 0

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Acta Chromatographica
Authors: Yuping Shen, Minhui Xu, Peipei Deng, Qinying Gu, Huawu Yin, Guohua Xia, Xiaobin Jia, Huan Yang, and James Tam

quality of bioactive chemical constituents in natural products [ 15 ]. Accordingly, in our previous studies, gallic acid, methyl gallate, and a few non-specific flavonoids such as rutin, kaempferol 3- O - β - d -glucopyranoside, and quercitrin, in Red Toon

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Acta Chromatographica
Authors: Omar M. Khalaf, Mosad A. Ghareeb, Amal M. Saad, Hassan M. F. Madkour, Ahmed K. El-Ziaty, and Mohamed S. Abdel-Aziz

:9, v/v), followed by PTLC eluted with (ethyl acetate: MeOH; 2.1:2.9; v/v) to give quercetin 3- O -α- l -rhamnopyranosyl-(1→6)-β- d -glucopyranoside (rutin) ( 5 ), while fraction (V) was purified on silica gel sub-column eluted with (EtOAc–MeOH; 17: 3, v

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High-performance liquid chromatography-mass spectrometry (HPLC-MS) method coupled with radical reaction for screening active ingredients from perennial fujimoto bean whole herb was established. The active ingredients, present in perennial fujimoto bean whole herb, possess scavenging effects towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide, peroxy radical, and hydroxyl radical. The radical scavenging abilities of these active ingredients were evaluated based on the relative peak areas in the HPLC chromatogram. The results indicate that potent antioxidants are present in the anhydrous methanol extract of perennial fujimoto bean whole herb. Based on HPLC-MS analysis, it was found that the scavenging ability can be mostly attributed to the presence of three compounds: cyanidin-3-o-β-d-glucopyranoside, troxerutin, and rutin. The structures were identified based on the MS and nuclear magnetic resonance (NMR) data. Free radical scavenging activity decreased in the following order: troxerutin > rutin > cyanidin-3-o-β-d-glucopyranoside.

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The rhizome of Sparganium stoloniferum Buch.-Ham has been used as a traditional Chinese folk medicine for thousands of years. Phenolic compounds are the main bioactive ingredients of the plant. In order to determine the content of phenolic compounds from different major cultivations, a reliable method has been developed using ultra-high performance liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry. Seven compounds, including rutin, kaempferol, p-hydroxybenzaldehyde, formononetin, ferulic acid, vanillic acid, and p-coumaric acid, were simultaneously measured in 10 min. The established approach was fully validated in terms of linearity, sensitivity, precision, repeatability as well as recovery, and successfully applied to determine seven phenolic compounds of Rhizoma Sparganii. This study may be helpful in the quality control of Rhizoma Sparganii and can offer technical support for the pharmacological and clinical study of related drugs.

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